PALB2 GENE MUTATION
Clinical trials for PALB2 GENE MUTATION explained in plain language.
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Scientists test new drug duo against tough cancers linked to faulty genes
Disease control Recruiting nowThis is an early-stage study to find a safe and tolerable dose of two oral drugs, olaparib and ASTX727, when given together. It is for adults with advanced solid tumors that have specific mutations in genes like BRCA1, BRCA2, PALB2, ATM, or CHEK2. The main goals are to check for …
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE1 • Sponsor: Pamela Munster • Aim: Disease control
Last updated Mar 31, 2026 12:12 UTC
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New hope for tough pancreatic cancers: testing targeted drug combos
Disease control Recruiting nowThis study is testing which of two different drug combinations works better for people with advanced pancreatic cancer that has specific genetic changes (BRCA1, BRCA2, or PALB2 mutations) and has stopped responding to their first treatment. It will compare a newer combination cal…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE2, PHASE3 • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated Mar 30, 2026 14:34 UTC
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Radical stem cell combo aims to outsmart tough cancers
Disease control Recruiting nowThis early-stage trial is testing a new treatment for people with metastatic pancreatic or breast cancer. The goal is to see if a combination of high-dose chemotherapy drugs, vitamins, and the patient's own stem cells is safe and can overcome the cancer's resistance to treatment.…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE1 • Sponsor: General Oncology, Inc. • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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New drug duo tested to fight tough cancers with genetic flaws
Disease control Recruiting nowThis early-stage study aims to find a safe and effective dose for combining two cancer drugs, niraparib and irinotecan. It is for adults with advanced solid tumors (like certain breast, ovarian, or pancreatic cancers) that have spread and have specific mutations in genes like BRC…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE1 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Mar 23, 2026 15:15 UTC
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New scan could better detect prostate cancer spread in High-Risk men
Diagnosis Recruiting nowThis study aims to determine if a PET-CT scan is better than standard MRI and bone scans at finding prostate cancer that has spread in men with specific inherited genetic mutations. Researchers will compare how well each method detects cancer in lymph nodes and distant organs in …
Matched conditions: PALB2 GENE MUTATION
Sponsor: Institute of Cancer Research, United Kingdom • Aim: Diagnosis
Last updated Mar 31, 2026 12:11 UTC
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Digital push to get more families tested for cancer genes
Knowledge-focused Recruiting nowThis study is testing two new digital approaches to improve cancer genetic counseling. The first part helps doctors contact family members of a patient with a cancer gene to encourage them to get tested. The second part helps patients and their doctors stay updated when a genetic…
Matched conditions: PALB2 GENE MUTATION
Phase: NA • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Mar 16, 2026 15:27 UTC