PALB2 GENE MUTATION
Clinical trials for PALB2 GENE MUTATION explained in plain language.
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New drug cocktail targets cancers with faulty DNA repair
Disease control Recruiting nowThis early-stage trial is testing whether combining two drugs—niraparib and irinotecan—can safely treat advanced solid tumors that have mutations in DNA repair genes like BRCA. The study will enroll 24 adults with various cancers, including breast, ovarian, pancreatic, and others…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE1 • Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New drug combo targets tough cancers in early trial
Disease control Recruiting nowThis early-phase study tests a combination of two oral drugs, olaparib and ASTX727, in adults with advanced solid tumors that have mutations in genes like BRCA1, BRCA2, PALB2, ATM, or CHEK2. The main goals are to find the safest dose and to check for side effects. About 18 partic…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE1 • Sponsor: Varun Monga, MBBS • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Experimental combo aims to overcome drug resistance in metastatic cancers
Disease control Recruiting nowThis early-stage trial is testing a combination of two chemotherapy drugs (melphalan and BCNU) plus vitamins B12b and C, followed by an infusion of the patient's own stem cells. The goal is to see if this approach is safe for people with metastatic pancreatic or breast cancer, es…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE1 • Sponsor: General Oncology, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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New scan may improve cancer detection for men with inherited risk
Diagnosis Recruiting nowThis study compares a new PET-CT scan (FCH-PET-CT) to standard imaging (bone scan and MRI/CT) to see which better finds cancer that has spread outside the pelvis in men with prostate cancer and specific DNA repair gene mutations. About 50 men with these mutations will be enrolled…
Matched conditions: PALB2 GENE MUTATION
Sponsor: Institute of Cancer Research, United Kingdom • Aim: Diagnosis
Last updated Jun 27, 2026 08:04 UTC
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Can digital tools make cancer genetic counseling more effective?
Knowledge-focused Recruiting nowThis study looks at two new approaches to cancer genetic counseling. The first helps doctors reach out to family members who may have inherited a cancer-related gene change, making it easier for them to get tested. The second uses an online portal to keep patients and their docto…
Matched conditions: PALB2 GENE MUTATION
Phase: NA • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC