OSTEO ARTHRITIS OF THE KNEE

This study compares two ways to realign the knee during surgery for people with arthritis and bow-leggedness. The goal is to see which method—kinematic or mechanical alignment—leads to better pain relief and function. One hundred adults with knee arthritis will be randomly assign…

This early study tests a single injection of a new polymer called ABR1 for knee osteoarthritis. 25 adults with moderate to severe knee pain will receive the injection and be monitored for 12 weeks for side effects. The goal is to see if the treatment is safe enough to study furth…

This study compares two ways to align the knee during total knee replacement in 80 obese adults (BMI 35 or higher). One method uses robotic or computer assistance, the other uses traditional manual tools. The goal is to see which approach leads to better knee movement and recover…

This study compares two types of total knee replacement surgery for people with knee osteoarthritis: one done manually and one assisted by a robotic device (VELYS). About 346 participants will be randomly assigned to one of the two surgeries and followed for a year to see which l…

This study tests a wearable device that delivers long-duration ultrasound to the knee to reduce pain and improve function in people with mild to moderate knee osteoarthritis. About 240 adults aged 65-85 with frequent knee pain will use the device over 12 weeks. The goal is to see…

This study tests a gel called Sensovisc, injected into the knee joint to reduce pain and improve movement in people with knee osteoarthritis. About 75 adults with moderate knee arthritis will receive the gel and be followed for 6 months. The goal is to see if the gel safely eases…

This study looks at whether a program called PREP helps veterans who need total knee replacement for osteoarthritis. The program includes exercises before surgery and a week of intense rehab after. Researchers will check pain, function, and mental health for up to a year after su…