OSA
Clinical trials for OSA explained in plain language.
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Sleep apnea pill shows promise in phase 3 trial
Symptom relief CompletedThis study tested a combination pill called AD109 against a placebo in 646 adults with obstructive sleep apnea who cannot tolerate CPAP machines. The goal was to see if the pill reduces breathing pauses during sleep. Participants took the medication or placebo for 6 months, and r…
Matched conditions: OSA
Phase: PHASE3 • Sponsor: Apnimed • Aim: Symptom relief
Last updated May 17, 2026 05:09 UTC
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New pill could ease sleep apnea without the mask
Symptom relief CompletedThis study tested a combination pill called AD109 (aroxybutynin and atomoxetine) against a placebo in 660 adults with obstructive sleep apnea who cannot or will not use a CPAP machine. The goal was to see if the pill reduces breathing pauses during sleep and improves fatigue. Par…
Matched conditions: OSA
Phase: PHASE3 • Sponsor: Apnimed • Aim: Symptom relief
Last updated May 15, 2026 11:57 UTC
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Mouth device may cut nightly bathroom runs in sleep apnea patients
Symptom relief CompletedThis study tested whether a mandibular advancement device (MAD), a mouthpiece that moves the jaw forward, can reduce how often people with obstructive sleep apnea wake up to urinate at night. Eleven adults with sleep apnea and at least two nightly bathroom trips took part. Partic…
Matched conditions: OSA
Phase: NA • Sponsor: Fernanda Yanez Regonesi • Aim: Symptom relief
Last updated May 05, 2026 11:56 UTC
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Sleep apnea pill shows promise in small trial
Symptom relief CompletedThis study tested whether a single dose of the sleep drug lemborexant could improve breathing and sleep quality in 10 adults with moderate-to-severe obstructive sleep apnea (OSA) who have a low arousal threshold. Participants spent two nights in a sleep lab, receiving either the …
Matched conditions: OSA
Phase: PHASE1, PHASE2 • Sponsor: Chulalongkorn University • Aim: Symptom relief
Last updated Apr 29, 2026 15:02 UTC
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Could sleep apnea speed up Alzheimer's? new study investigates
Knowledge-focused CompletedThis study looked at whether obstructive sleep apnea (OSA) might help cause Alzheimer's disease. Researchers studied 182 older adults aged 65-85, some with and some without sleep apnea, using brain scans and breathing tests. The goal was to understand how sleep disruptions from a…
Matched conditions: OSA
Phase: PHASE1 • Sponsor: University of California, San Diego • Aim: Knowledge-focused
Last updated May 13, 2026 16:00 UTC
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Can tailored exercise help lung disease patients regain strength?
Knowledge-focused CompletedThis study looked at how a mix of home and in-person exercise sessions affects muscle loss and fatigue in people with chronic respiratory diseases like COPD, sleep apnea, or lingering COVID-19 symptoms. 72 adults aged 30-85 participated in 18 tailored exercise sessions. The goal …
Matched conditions: OSA
Phase: NA • Sponsor: Texas A&M University • Aim: Knowledge-focused
Last updated May 12, 2026 13:41 UTC
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Scientists uncover how sleep apnea drug combo works
Knowledge-focused CompletedThis study looked at how two drugs, atomoxetine and oxybutynin, affect throat muscles in people with obstructive sleep apnea (OSA). 27 adults with OSA took part to help researchers understand why the combination improves breathing during sleep. The goal was not to test a new trea…
Matched conditions: OSA
Phase: PHASE1, PHASE2 • Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated May 08, 2026 12:02 UTC
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Ultrasound reveals diaphragm changes in sleep apnea patients
Knowledge-focused CompletedThis study looked at how well the diaphragm works in people with obstructive sleep apnea (OSA) using ultrasound. Researchers measured diaphragm thickness and movement in 60 adults with OSA. The goal was to see if these measurements relate to how severe the sleep apnea is. This wa…
Matched conditions: OSA
Sponsor: Mansoura University • Aim: Knowledge-focused
Last updated May 07, 2026 18:42 UTC