OSA

This study tested the Inspire system, a device that stimulates a nerve in the neck to keep the airway open during sleep. It involved 44 adults in Singapore with moderate-to-severe obstructive sleep apnea who could not use CPAP. The main goal was to confirm the device works proper…

This study tested whether using a CPAP machine (a device that helps you breathe during sleep) can also improve oral frailty (weakness in the mouth) and dysphagia (trouble swallowing) in people with obstructive sleep apnea. Researchers followed 450 adults aged 50 and older for six…

This study tested whether a dental mouthpiece (mandibular advancement device) can reduce frequent nighttime urination in adults with obstructive sleep apnea. Eleven participants who woke up to pee at least twice a night used the device and tracked their bathroom visits. The goal …

This study tested a new combination pill called AD109 for obstructive sleep apnea (OSA) in 646 adults who could not tolerate CPAP machines. The pill aims to reduce breathing pauses during sleep by targeting brain chemicals. Results will show if it improves the apnea-hypopnea inde…

This study tested a new medication called AD109 (a combination of two drugs) to treat obstructive sleep apnea in adults who cannot or will not use a CPAP machine. About 660 participants took either the pill or a placebo for one year. The main goal was to see if the pill reduces t…

This small study tested whether the sleep medication lemborexant (Dayvigo) can help people with moderate-to-severe obstructive sleep apnea (OSA) who have a low arousal threshold—meaning they wake up easily during sleep. Ten untreated adults each took the drug or a placebo on two …

This completed Phase 1 study looked at whether obstructive sleep apnea (OSA) might contribute to Alzheimer's disease. Researchers studied 182 older adults aged 65-85 with and without OSA, using brain scans and breathing tests. The goal was to understand how sleep disruptions like…

This study looked at how well the diaphragm works in people with obstructive sleep apnea (OSA). Researchers used ultrasound to measure diaphragm movement in 60 adults with OSA. The goal was to see if diaphragm function is linked to how severe the sleep apnea is.

This study looked at how two drugs, atomoxetine and oxybutynin, affect throat muscles in people with obstructive sleep apnea (OSA). The goal was to understand why the combination works better than either drug alone. 27 adults with OSA took part, and researchers measured muscle ac…

This study looked at how a mix of home and on-site resistance training affects muscle loss and fatigue in people with chronic respiratory diseases like COPD, obstructive sleep apnea, or lingering COVID-19 symptoms. 72 adults aged 30-85 completed 18 exercise sessions. Researchers …