OLIGODENDROGLIOMA

This study tests the safety and effectiveness of giving two cancer drugs (cetuximab and bevacizumab) directly into the brain's arteries each month for children and young adults under 22 with brain tumors that have come back or not responded to treatment. About 20 participants wil…

This early-phase trial tests a personalized vaccine called Tamavaq NeoVaccine in 29 adults with newly diagnosed glioma, a type of brain cancer. The vaccine is designed using AI and quantum mechanics to target unique mutations in each patient's tumor, aiming to train the immune sy…

This study compares two types of radiation therapy for people with slow-growing brain tumors (IDH-mutated gliomas). Proton therapy aims to better protect healthy brain tissue than standard photon therapy. The trial will check if proton therapy is as effective at controlling the t…

This early-stage study tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and check for side effects. About 102 participants will take the drug once or several times a week.

This study tests whether adding the drug olutasidenib to standard chemotherapy can help children and young adults with a rare, aggressive brain cancer called IDH1-mutant high-grade glioma live longer. About 60 participants will receive the combination as maintenance therapy after…

This study tests a combination of two drugs (ATRA and retifanlimab) in people with a specific type of brain tumor (IDH-mutant glioma) that has returned after standard treatment. The goal is to see if this combo can shrink tumors or slow their growth by helping the immune system a…

This study is for people with a specific type of slow-growing brain tumor (oligodendroglioma) that needs treatment beyond surgery. The goal is to see if waiting to start radiation until the tumor grows back can help protect memory and thinking skills, without shortening how long …

This study tests a drug called safusidenib in people with a type of brain tumor (glioma) that has a specific gene mutation (IDH1). The trial has three parts: one for recurrent tumors, one for high-risk tumors after standard treatment, and one for a specific tumor type after surge…

This study is for adults with a type of brain tumor called oligodendroglioma. The goal is to see if a new combination of chemotherapy drugs (lomustine and temozolomide) can delay the need for radiation therapy, which can cause long-term side effects like memory and thinking probl…

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who have memory or thinking problems. About 125 participants will receive virtual one-on-one coaching sessions over 8 weeks, learning problem-solving and relaxation techniques. The goal is to see…

This study is testing whether a program called FearLess can help people with brain tumors and their caregivers cope with the fear that the cancer might come back. Researchers want to see if the program is practical and well-liked by participants. About 112 patients and caregivers…