OBESITY (BMI>30)

This trial tests whether a weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can improve blood sugar control and reduce the need for insulin in adults with obesity and type 2 diabetes. Participants have poorly controlled diabetes despite taking standard medication…

This study evaluates the safety and effectiveness of the Allurion Gastric Balloon System, a swallowable balloon placed in the stomach to help with weight loss. It involves 250 adults aged 22–65 with a BMI between 30 and 40. The balloon is swallowed and later passes naturally, avo…

This study looks at whether replacing sugary or refined-carb foods with one avocado each day can reduce inflammation and improve how the body handles insulin. It involves 38 overweight or obese adults with high inflammation markers. Participants will eat an avocado daily for four…

This phase 2 trial tests whether semaglutide, a weekly injection already used for weight loss, can reduce chronic low back pain in adults with obesity. Researchers will compare semaglutide to a placebo over 52 weeks in 250 participants, measuring changes in pain severity, disabil…

This early-phase study will test how insulin given as a nasal spray affects nerve activity and blood flow in the brain and legs. Researchers will compare 64 adults with obesity and insulin resistance to healthy-weight individuals. The goal is to understand how obesity changes the…

This study investigates how taurine—a natural amino acid linked to inflammation and cell health—differs between metabolically healthy and unhealthy older women with obesity. Researchers will measure taurine levels before and after a 16-week combined exercise program. The goal is …

This study looks at how incretin-based therapies (like GLP-1 drugs used for weight loss) affect breathing in people with obesity. Researchers will analyze data from 48 adults aged 25-60 with a BMI of 30 or higher. They will use machine learning to find patterns that predict impro…

This study will test whether a therapeutic patient education program is acceptable and useful for adults living with obesity and related conditions like diabetes or joint problems. About 42 participants will take part in a one-day group session and follow-up workshops, then answe…

This study will compare weight-loss plans made by ChatGPT with those made by a human dietitian. 21 adults with obesity will be split into three groups: one gets AI-only advice, one gets a dietitian's plan, and one gets a combination of both. The goal is to see which approach lead…