NON-SMALL CELL LUNG CANCER (NSCLC)

This study looks at the best way to manage high cholesterol caused by the targeted therapy lorlatinib in people with advanced ALK-positive non-small cell lung cancer. Some participants receive standard cholesterol-lowering drugs, while others get a more intensive combination. The…

This early-stage study tests a new tablet, LT-010391, in people with advanced solid tumors (lung, colon, or pancreatic cancer) that have a specific genetic change called KRAS G12D. The main goals are to check safety and find the right dose. About 198 participants who have tried o…

This study tests a combination of the targeted drug limertinib plus chemotherapy (etoposide and carboplatin) in 30 people with a specific type of lung cancer. These patients have a mutation in the EGFR gene and their cancer has changed from non-small cell to small cell lung cance…

This study tests an experimental oral drug, BPI-572270, in 120 adults with advanced solid tumors (lung, colorectal, or pancreatic cancer) that have specific RAS gene mutations. The trial has two phases: first to find a safe dose and check for side effects, then to see if the drug…

This study tests an experimental drug called QLS5132, given with other cancer treatments, for people with advanced solid tumors like stomach, lung, endometrial, and ovarian cancers. The goal is to find safe doses and see if the combination shrinks tumors. About 626 participants w…

This study tests whether a higher dose of furmonertinib alone works better than a standard dose combined with chemotherapy for people with a specific type of lung cancer (EGFR-mutated) that has spread to the brain. About 60 adults who have not had prior treatment will be enrolled…

This Phase 2 trial tests JSKN033, a combination of two drugs (a HER2-targeted antibody-drug conjugate and a PD-L1 inhibitor), in 160 people with advanced non-small cell lung cancer that cannot be cured. The study will first find the best dose, then expand to see how well it shrin…

This phase 3 trial tests whether adding Huaier granules (a traditional Chinese medicine) to microwave ablation improves outcomes for people with stage IA non-small cell lung cancer who cannot have surgery. 180 participants will be randomly assigned to receive ablation alone or ab…

This study is developing a blood test called NeutroFlow that measures specific immune cells (neutrophils) to predict whether cancer patients will benefit from immunotherapy. Researchers will collect blood samples from 600 patients with several types of cancer before they start tr…

This early-stage trial tests whether the drug ponsegromab can help adults with advanced non-small cell lung cancer who are losing muscle mass (cachexia). About 80 participants will receive either ponsegromab or a placebo. The study measures changes in muscle size and physical fun…

This study tests whether a wearable device and digital platform can help people recover better after lung cancer surgery. About 126 patients with non-small cell lung cancer will either use the wearable system or receive standard care. The system tracks heart rate, oxygen levels, …

This pilot study will test whether a 6-month athletic program can improve lung function and quality of life in 10 patients who had surgery for non-small cell lung cancer. Participants will follow a supervised exercise plan and be compared to similar patients who did not exercise.…

This study looks at how Traditional Chinese Medicine (TCM) body patterns, like tongue and pulse readings, relate to how well targeted lung cancer drugs work. About 3000 people with a specific type of lung cancer will be followed for up to 5 years. Researchers will collect TCM inf…