NEUROPATHY

This study tests whether a spinal cord stimulator can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. About 25 adults will receive the device and be monitored for changes in pain, circulation, and vessel stiffness. The goal is to…

This study tests a prescription laser device for home use to temporarily relieve foot pain caused by idiopathic peripheral neuropathy. About 32 adults with constant foot pain for at least 3 months will use the device and report their pain levels over 6 weeks. The goal is to see i…

This small pilot study tests whether using a hand-held vibrating device for just 3 minutes each day can safely reduce nerve pain and numbness in the hands caused by chemotherapy. Researchers will enroll 16 adults who completed certain types of chemotherapy at least 60 days ago. T…

This study tests a non-invasive treatment called transcutaneous pulsed radiofrequency for chronic pain after shingles (postherpetic neuralgia). Researchers want to see if it can reduce pain better than current options. The trial will enroll 35 adults with this condition and measu…

This study tests whether a 12-week online tai chi program is practical and helpful for cancer survivors who have nerve damage and balance problems from chemotherapy. About 21 adults who finished chemo at least 3 months ago will join virtual tai chi classes. The goal is to see if …

This study aims to understand why some people develop nerve pain after a spinal cord injury. Researchers will use pain tests and body measurements to study how the nervous system changes. The study involves 300 participants, including people with spinal cord injuries and healthy …

This study gathers medical information from 200 adults with nerve, muscle, or autonomic nervous system disorders who are not already in other NIH studies. Researchers will perform standard tests like nerve conduction studies, muscle exams, and sweat tests to create a database for…

This study looks at how nerves work in people who develop nerve damage from the chemotherapy drug cisplatin. Researchers will use a special test to measure nerve signals in 60 adults starting cisplatin treatment. The goal is to better understand the nerve damage and find early wa…

This study aims to find out how often people with cystic fibrosis-related diabetes (CFRD) develop eye, kidney, and nerve problems, as well as heart disease risks. Researchers will enroll 200 adolescents and adults with CFRD for at least 5 years. The goal is to better understand t…

This study looks at how a drug called enfortumab vedotin affects the nerves of people with advanced bladder cancer that has spread. Researchers will measure nerve function with simple tests before and during treatment. The goal is to better understand and possibly prevent nerve d…

This study analyzes DNA from 575 breast cancer patients who received the chemotherapy drug paclitaxel. Researchers want to find genetic differences that make some people more likely to develop nerve damage (peripheral neuropathy) from treatment. By comparing DNA from those who ha…

This study is collecting personal, clinical, and test information from 4,000 adults with peripheral neuropathy (nerve damage). The goal is to create a detailed record of all types of peripheral neuropathies and see if ultrasound can help diagnose and track the disease. No new tre…

This study is gathering information from 1,000 intensive care patients to learn what normal pupil measurements look like when using a special device called a pupillometer. The goal is to create a standard set of values for pupil size and reactivity, which can help doctors better …