NEURODEGENERATIVE DISEASE

This phase 3 trial tests a single dose of NTLA-2001, a gene-editing therapy, in 60 adults with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN), a rare genetic disease that damages nerves. Participants are randomly assigned to receive either the active treatmen…

This study tests a new radioactive tracer called [18F]NIDF that binds to tau tangles in the brain, which are linked to Alzheimer's and other neurodegenerative diseases. Researchers will give the tracer to 20 healthy volunteers and patients, then use PET scans to see how well it h…

This study tests whether 8 weeks of mindfulness classes, taken together by people with Parkinson's and their family caregivers, can reduce negative emotions like stress, anxiety, and depression. About 200 Chinese patient-caregiver pairs will either take the classes or continue us…

This study tests a walking meditation program called iWalk for adults with neurodegenerative diseases like multiple sclerosis. The goal is to see if it's feasible and helps improve resilience, stress regulation, and thinking skills. Researchers will enroll 90 participants and mea…

This study screens up to 5,000 healthy volunteers and people at risk for psychiatric or neurodevelopmental disorders like autism. Participants undergo interviews, cognitive tests, and other evaluations to see if they qualify for future research studies at NIH. The goal is to buil…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study aims to find early markers of Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will compare results from 180 people with these conditions and healthy volunteers. The goal is to improv…

This study looks at how moderate wine consumption changes tiny particles called extracellular vesicles, which help cells communicate. Eight healthy adults aged 35-65 will drink red wine, white wine, or water, and researchers will analyze their blood for changes in these particles…

This study is looking at how people with conditions like schizophrenia, bipolar disorder, depression, and neurological diseases (such as Alzheimer's or stroke) perform on computer-based thinking tests. The goal is to create a detailed map of cognitive strengths and weaknesses acr…

This study looks at whether using a swallow gel or a semi-solid vehicle can help people with neurological conditions swallow pills more easily and safely. Researchers will observe 500 participants, including patients with swallowing disorders and healthy volunteers, as they swall…

This study uses a special brain scan called PET to measure a protein called tau, which builds up in the brains of people with diseases like Alzheimer's and frontotemporal degeneration. Researchers will look at how tau buildup relates to memory and thinking problems over time. The…