METASTATIC MALIGNANT NEOPLASM

This phase 2 trial tests the drug talazoparib in 150 people with advanced cancers that have not responded to standard treatments. Participants must have specific gene changes in BRCA1, BRCA2, or related DNA repair genes. The drug works by blocking an enzyme that helps cancer cell…

This study tests whether choosing cancer treatment based on the genetic makeup of a patient's tumor works better than standard therapy. Over 1,300 people with metastatic cancer are randomly assigned to receive either a targeted drug matched to their tumor's mutations or standard …

This study tests whether adding cryoablation—a procedure that freezes and kills cancer cells—can improve the effectiveness of standard immunotherapy in people with metastatic cancer. Fifteen participants will receive both treatments, and researchers will measure how many patients…

This study looks at how well two drugs, haloperidol and lorazepam, can control severe agitation and confusion (delirium) in people with advanced cancer who are in palliative care. About 110 patients will be enrolled to compare different drug approaches. The goal is to improve com…

This phase III trial tests whether the stimulant methylphenidate (Ritalin) combined with physical activity can reduce cancer-related fatigue in 212 patients with metastatic cancer who are receiving anti-PD1 immunotherapy. Participants are randomly assigned to receive either methy…

This study tests whether adding a short course of the steroid dexamethasone to a physical activity program can better reduce severe fatigue in people with advanced cancer. About 90 participants will be randomly assigned to receive either a high or low dose of dexamethasone along …

This study tests whether giving haloperidol alone or with chlorpromazine can safely calm severe agitation and confusion (delirium) in 70 advanced cancer patients in a palliative care unit. The main goal is to see if the drugs improve sedation scores within 24 hours. It is a phase…

This study compares two radiation treatments for people whose non-melanoma cancer has spread to the brain with 4 to 15 tumors. One method, stereotactic radiosurgery, delivers a high dose only to the tumors, while the other treats the whole brain. The goal is to see which better c…

This study asks cancer patients and their caregivers whether they would rather wait in an exam room or a waiting room when they arrive at the clinic. The goal is to understand their preferences to improve the clinic experience. About 406 people with advanced cancer and their care…

This study looks at how serious money problems are for people with advanced cancer. Researchers will survey 141 patients to measure financial distress and see if it is linked to their symptoms and quality of life. The goal is to understand the burden of cancer costs, not to test …