METASTATIC MALIGNANT NEOPLASM

This study looks at whether freezing cancerous tumors (cryoablation) can boost the effects of standard immunotherapy in people with metastatic cancer. About 15 participants will receive cryoablation on top of their usual treatment. The goal is to see if this combination leads to …

This early-phase trial tests the safety and best doses of two drugs (bevacizumab and temsirolimus) given alone or with other medicines (valproic acid or cetuximab) in people with advanced cancer or certain non-cancerous diseases that are hard to treat. The goal is to find the hig…

This study compares two radiation treatments for people whose cancer has spread to the brain (but not from melanoma). One is stereotactic radiosurgery, which targets tumors precisely with a high dose. The other is whole brain radiation, which treats the entire brain with lower do…

This study tests a drug called talazoparib in people with advanced cancers that have not responded to standard treatments. The drug works by blocking an enzyme that helps cancer cells survive, especially in tumors with changes in the BRCA genes or related DNA repair genes. The go…

This study looks at whether a medication called methylphenidate (often used for ADHD) combined with physical activity can reduce severe tiredness in people with advanced cancer who are on immunotherapy. About 212 participants will be randomly assigned to receive either the drug o…

This study looks at whether haloperidol, given alone or with chlorpromazine, can safely reduce severe agitation and confusion (delirium) in people with advanced cancer who are in a palliative care unit. About 70 participants will receive the drugs and be monitored for 24 hours. T…

This study tests whether adding a short course of the steroid dexamethasone to a physical activity program can reduce severe fatigue in people with advanced cancer. About 90 participants will be randomly assigned to receive either a high or low dose of dexamethasone along with ex…

This study looks at how well two drugs, haloperidol and lorazepam, can control severe agitation and confusion (delirium) in advanced cancer patients receiving palliative care. About 110 patients whose delirium did not improve with low-dose haloperidol will be given different drug…

This study looks at whether cancer patients and their caregivers prefer to wait in an exam room instead of a waiting room when visiting a supportive care clinic. About 406 participants will share their opinions through a questionnaire. The goal is to understand what makes the cli…

This study looks at whether analyzing the genetic changes in a patient's tumor can help doctors pick a more effective targeted therapy for metastatic cancer. Over 1,300 patients with cancer that has spread are randomly assigned to receive either a treatment chosen based on their …

This study looks at how serious money problems are for people with advanced cancer. Cancer care can be very expensive, and the stress from debt and high costs may make physical symptoms and quality of life worse. About 141 patients will fill out a short survey to measure their fi…