METASTATIC COLORECTAL CANCER (CRC)
Clinical trials for METASTATIC COLORECTAL CANCER (CRC) explained in plain language.
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New hope for advanced colon cancer: experimental drug combo enters phase 3 trial
Disease control Recruiting nowThis phase 3 study tests whether a new drug called ivonescimab, combined with standard chemotherapy (FOLFOX), works better than the current standard treatment (bevacizumab plus FOLFOX) for people with metastatic colorectal cancer that has spread. About 600 adults who have not had…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase: PHASE3 • Sponsor: Summit Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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New pill targets Hard-to-Treat cancers in early trial
Disease control Recruiting nowThis early-phase study tests a new drug called BBO-11818 in people with advanced cancers that have a KRAS mutation, including lung, pancreatic, and colorectal cancers. The main goals are to check safety and find the best dose, while also seeing if the drug can shrink tumors. Abou…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase: PHASE1 • Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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New hope for Tough-to-Treat colon cancer? early trial launches
Disease control Recruiting nowThis early-phase study is testing whether a new drug called SAR445877, when added to standard chemotherapy and a targeted therapy, is safe for people with advanced colorectal cancer that hasn't spread widely yet. About 41 adults will take part. The main goal is to find any side e…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New hope for advanced colon cancer: drug combo trial launches
Disease control Recruiting nowThis Phase II trial is testing a combination of the targeted drug fruquintinib with standard chemotherapy as a first treatment for people with advanced colorectal cancer that cannot be removed by surgery or has spread. Fifty participants will receive the drugs in 28-day cycles, w…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase: PHASE2 • Sponsor: The Methodist Hospital Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Custom immune cells take on advanced colorectal cancer in early trial
Disease control Recruiting nowThis early-stage trial is testing a personalized treatment called iNeo-Vac-T01 for people with advanced colorectal cancer. The therapy uses a patient's own immune cells, which are trained in a lab to recognize and attack unique markers on their tumor. The study will enroll 20 par…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase: PHASE1 • Sponsor: Ying Yuan, MD • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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New chemo cocktail aims to outperform standard care in colorectal cancer
Disease control Recruiting nowThis Phase 3 trial tests whether a new combination of chemotherapy drugs (NALIRIFOX) plus targeted therapy works better than the standard FOLFOX regimen for people with metastatic colorectal cancer that has not been treated before. About 144 participants will receive one of the t…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase: PHASE3 • Sponsor: Shanghai Zhongshan Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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CBD tested as shield against Chemo's nerve pain
Prevention Recruiting nowThis early-phase trial tests whether taking CBD capsules can prevent nerve damage caused by the chemotherapy drug oxaliplatin in people with colorectal cancer. Thirty participants will be randomly assigned to receive either CBD plus standard chemo or chemo alone. The main goal is…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase: EARLY_PHASE1 • Sponsor: Fox Chase Cancer Center • Aim: Prevention
Last updated Jun 27, 2026 07:55 UTC
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Researchers hunt for clues to improve colorectal cancer Drug's success
Knowledge-focused Recruiting nowThis study tracks 300 adults with advanced colorectal cancer who are taking the drug fruquintinib. Researchers want to find out which patient or tumor features help the drug work best and improve survival. The goal is to learn from real-world use to better match patients with eff…
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Phase: NA • Sponsor: Federation Francophone de Cancerologie Digestive • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Blood test may help decide who gets second chance at targeted cancer therapy
Knowledge-focused Recruiting nowThis observational study looks at whether a liquid biopsy (ctDNA test) can help select metastatic colorectal cancer patients who might benefit from retreatment with anti-EGFR drugs. Researchers will collect data from 250 patients already screened in a prior trial. The goal is to …
Matched conditions: METASTATIC COLORECTAL CANCER (CRC)
Sponsor: Niguarda Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC