MANTLE CELL LYMPHOMA (MCL)

This study tests an experimental drug called NX-5948 in adults with certain blood cancers (like CLL or lymphoma) that have come back or stopped responding to treatment. The drug works by breaking down a protein that helps cancer cells grow. The main goals are to find a safe dose …

This study tests a combination of two drugs, pirtobrutinib and rituximab, in people with a slow-growing form of mantle cell lymphoma who have not had treatment before. The goal is to see if this drug pair can shrink or control the cancer without using standard chemotherapy. About…

This study tests a combination of two drugs (orelabrutinib and rituximab) in people newly diagnosed with a slow-growing type of mantle cell lymphoma. Some may also receive a stem cell transplant using their own cells. The goal is to see how well the treatment shrinks or eliminate…

This early-stage study tests a new drug called NX-2127 in adults with certain blood cancers (like CLL or lymphoma) that have returned or not improved after other treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. About …

This study is testing a combination of three drugs (orelabrutinib, lisaftoclax, and rituximab) in people with a fast-growing type of blood cancer called mantle cell lymphoma that has high-risk features. The goal is to see how well the treatment shrinks or eliminates the cancer an…

This early-phase trial tests a new type of immunotherapy called CD19x22 CAR T cells in people aged 16 and older with B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. The therapy uses the patient's own immune cells, modified to attack two targets on ca…

This early-phase study tests a new drug called LTZ-301 in 42 adults with certain types of non-Hodgkin lymphoma that have not responded to at least two prior treatments. The main goal is to check the drug's safety and find the right dose. Researchers will also look for signs that …

This study tests a combination of three drugs (pomalidomide, orelabrutinib, and zuberitamab) in people with untreated mantle cell lymphoma, a type of blood cancer. The goal is to see if the treatment can reduce cancer cells to undetectable levels after six cycles. Participants wh…

This study tests a new type of CAR-T cell therapy that targets two proteins (CD19 and CD20) on cancer cells. It is for adults with certain B cell blood cancers (like lymphoma or leukemia) that have not responded to other treatments. The goal is to see if these specially engineere…

This study tests a combination of two treatments—relmacabtagene autoleucel (a type of cell therapy) and sintilimab (an immunotherapy drug)—in 30 adults with relapsed or refractory B-cell lymphoma (including diffuse large B-cell, mantle cell, and follicular lymphoma). The goal is …

This study is a registry that collects information from about 2,950 adults with certain blood cancers (like CLL, DLBCL, and others) in Germany. Researchers will track what treatments patients receive, how well they work, and how patients feel over time. No new drugs or treatments…