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New Pill-and-Infusion combo aims to tame rare blood cancer without chemo

NCT ID NCT07285590

Recruiting now Disease control Sponsor: Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a combination of two drugs, pirtobrutinib (a pill) and rituximab (an infusion), in 50 adults newly diagnosed with a slow-growing form of mantle cell lymphoma. The goal is to see if this drug pair can shrink or control the cancer without the need for standard chemotherapy. Participants will receive the treatment for several cycles, and researchers will track how many achieve complete remission after 6 cycles.

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Conditions

The condition(s) this trial relates to.

lymphoma mantle cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MANTLE CELL LYMPHOMA (MCL)

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Clínica Universidad Navarra

    RECRUITING

    Madrid, Madrid, 28027, Spain

  • Clínica Universidad Navarra

    RECRUITING

    Pamplona, Pamplona, 31008, Spain

  • Hospital Clinic de Barcelona

    RECRUITING

    Barcelona, Barcelona, 08036, Spain

  • Hospital Clínico Universitario Virgen de la Arrixaca

    RECRUITING

    El Palmar, Murcia, 30120, Spain

  • Hospital Clínico de Valencia

    RECRUITING

    Valencia, Valencia, 46010, Spain

  • Hospital Costa del Sol

    RECRUITING

    Marbella, Málaga, 29603, Spain

  • Hospital General Universitario Gregorio Marañón

    RECRUITING

    Madrid, Madrid, 28007, Spain

  • Hospital Ramon y Cajal

    RECRUITING

    Madrid, Madrid, 28034, Spain

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    RECRUITING

    Madrid, Madrid, 28041, Spain

  • Hospital Universitario de Salamanca

    RECRUITING

    Salamanca, Salamanca, 37007, Spain

  • Hospital Universitario y Politécnico La Fe

    NOT_YET_RECRUITING

    Valencia, Valencia, 46026, Spain

  • INSTITUT CATALÀ D'ONCOLOGIA (ICO). Hospital Germans Trias I Pujol.

    NOT_YET_RECRUITING

    Badalona, Barcelona, 08916, Spain

  • Institut Català d'oncologia de L'Hospitalet (ICO-L'Hospitalet)

    NOT_YET_RECRUITING

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Instituto Português de Oncologia de Lisboa Francisco Gentil

    RECRUITING

    Lisbon, Lisbon District, 1099-023, Portugal

  • Unidade Local De Saude De Santa Maria E.P.E.

    NOT_YET_RECRUITING

    Lisbon, Lisbon District, 1649-028, Portugal

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