MALOCCLUSION

This study will develop and test artificial intelligence (AI) models that analyze facial photos, 3D scans, and CT images to help diagnose conditions like misaligned jaws and facial deformities. About 2,000 participants will have their existing medical images used to train and tes…

This study checks if an artificial intelligence (AI) system can analyze dental X-rays as accurately as the standard manual method. About 55 people with crooked teeth or jaw issues will have their X-rays read by both AI and a human expert. The goal is to see if AI can be a reliabl…

This study compares two common clear aligner trimming-line designs to see which one feels more comfortable to wear. Seventy orthodontic patients who already wear one design on their upper teeth and the other on their lower teeth will rate their comfort after at least four weeks. …

This study compares two techniques to speed up the movement of upper canine teeth during orthodontic treatment: micro-osteoperforation (creating tiny holes in the jawbone) and photobiomodulation (low-level laser therapy). 75 people needing premolar extractions as part of braces w…

This trial compares three simple methods to ease pain after getting braces tightened: acupressure (pressing a spot on the hand), ibuprofen, and chewing sugar-free gum. 105 people aged 15 to 35 will be randomly assigned to one of the three groups. They will rate their pain over th…

This study compares three types of orthodontic separators (elastomeric, Kesling, and customized tie wire) in 144 people aged 12–25 who need braces. Researchers will measure how well each separator creates space between teeth, how much pain it causes, plaque buildup, and effects o…

This study tests whether a special dental surgery called PAOO, done before braces, helps move back molars faster and with less discomfort. Forty adults with misaligned teeth will be randomly assigned to get braces alone or braces plus PAOO. Researchers will measure tooth movement…

This study tests whether taking a daily vitamin D supplement (1000 IU) for 4 months can reduce pain, speed tooth movement, and improve bone density in people getting braces. Researchers will compare vitamin D to a placebo in 48 adults aged 18-35 with crooked teeth. Participants w…

This study looks at whether the way your jaw and teeth fit together (called malocclusion) is related to your body posture. Researchers will use a 3D scanner to measure the spine's curves and alignment in people with different types of jaw misalignment. The goal is to better under…

This study looks at how two types of clear aligners—3D-printed versus thermoformed—affect bone metabolism in adults with minor crowding. Thirty participants will be randomly assigned to one type, and researchers will measure changes in a bone-related protein and gum health. The g…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This study uses computer simulations to compare custom-made implants with standard miniplates for fixing the upper jaw after surgery. Researchers will analyze stress on the implants and bone, as well as jaw movement, in two different surgical scenarios. The goal is to provide ins…