MALIGNANT NEOPLASM OF BREAST

This early-stage trial tests whether a DNA vaccine targeting mammaglobin-A (a protein found on breast cancer cells) is safe and can boost the immune system against cancer. About 27 adults with ER+, HER2- breast cancer will receive the vaccine while undergoing standard hormone the…

This study tests a combination of two drugs, selumetinib and olaparib, in people with advanced or recurrent solid tumors (including breast, digestive, female/male genital, and thyroid cancers). The goal is to find the safest dose and see if it can help control the cancer. Up to 9…

This early-phase study tests a special bacteria (Clostridium novyi-NT) injected directly into tumors, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors that haven't responded to standard treatments. The goal is to find the safest dose and s…

This early-stage trial tests a new two-part treatment for people with advanced breast cancer that has not responded to standard therapies. Participants receive a single infusion of their own engineered immune cells (CLBR001) followed by cycles of a biologic drug (ABBV-461). The m…

This study is testing whether a short, daily mind-body exercise program delivered through a phone app can help reduce stress and physical symptoms for women newly diagnosed with breast cancer. Participants are randomly assigned to either use the app for 14 days before starting ch…

This study is testing a new way to take MRI pictures of the breast using a very low magnetic field. The goal is to see if this method can produce clearer images of breast cancers. About 40 people will take part, and the new images will be compared with standard mammograms, ultras…

This study looks at how the drug Palbociclib is actually used in everyday medical practice for people with a specific type of advanced breast cancer (HR+/HER2-). Researchers will analyze anonymous medical records to see how long patients take the drug and how it affects their nee…