LUNG TRANSPLANT

This study tests whether the drug Belumosudil can prevent chronic lung allograft dysfunction (CLAD), a form of long-term rejection, in 234 lung transplant recipients who show early signs of lung injury on biopsy. Participants will take Belumosudil or a placebo for 52 weeks alongs…

This study tests whether adding tocilizumab (a drug that reduces inflammation) to standard anti-rejection medicines can prevent chronic lung allograft dysfunction (CLAD) in lung transplant recipients. 350 adults receiving their first lung transplant will be randomly assigned to g…

This early study tests a new way to use a heart-lung machine (ECMO) to support people with severe pulmonary hypertension and right heart failure while they wait for a lung transplant. The goal is to see if this approach can keep patients alive and stable until transplant without …

This study looks at whether 12 sessions of Latin dance can help people who have had a lung transplant feel better emotionally and physically. Researchers will measure changes in anxiety, depression, fear of movement, and balance. The study involves 52 adults who can walk and have…

This study tests whether up to 12 phone-based health coaching sessions over 12-16 weeks can improve emotional health and self-management in adults waiting for a lung transplant. 230 participants will be compared to a group receiving usual care. The goal is to see if coaching help…

This study aims to understand why some people who get a lung transplant develop rejection while others do not. Researchers will follow 100 adults who have had or are waiting for a lung transplant for up to 4 years, using blood tests, imaging scans, and lung function tests. No new…

This study collects tissue samples from 7,000 adults with lung cancer, COPD, lung transplants, or other chest diseases. The samples are stored in a repository to help researchers better understand how these diseases start, how to diagnose them early, and how to improve treatment.…

This study is a large registry that will collect information from up to 10,000 lung transplant recipients across the US. The goal is to see how well donor lungs that were kept and checked using the OCS Lung system perform over time. Researchers will track survival rates and how w…

This study compares two ways to perform double lung transplants: without a heart-lung machine (off-pump) or using a special heart-lung support called VA ECMO. The goal is to see which method leads to fewer serious lung complications and better survival. About 228 adults getting d…