LUNG CARCINOMA

This early-phase study tests a drug called veliparib combined with two standard chemotherapy drugs (carboplatin and paclitaxel) in people with advanced solid tumors who also have liver or kidney dysfunction. The main goals are to find the safest dose and understand how the body p…

This early-stage study tests a new radioactive tracer called 18F-αvβ6-BP to see if it can safely and effectively image several types of cancer, including breast, colorectal, lung, and pancreatic cancers. About 27 adults with primary or metastatic cancer will receive the tracer an…

This study tests whether metformin, a safe and widely used diabetes medicine, can reduce the risk of lung cancer in overweight or obese former smokers who are at high risk. About 50 participants will take metformin extended-release pills for 6 months. Researchers will measure cha…

This early-phase trial tests a MUC1 vaccine in 50 current or former smokers at high risk for lung cancer. The vaccine aims to train the immune system to recognize and destroy abnormal cells before they become cancer. Researchers are checking for side effects and whether the vacci…

This study looks at whether a yoga program can help cancer patients and their partners improve physical function, quality of life, and reduce symptoms like fatigue and distress during radiation therapy. About 600 patients with lung, head and neck, or esophageal cancer, along with…

This study was designed to look at how community cancer clinics test for biomarkers in common cancers like lung, breast, and colorectal cancer. The goal was to find out if testing is fast and accurate, and to spot any differences in how tests are done. However, the study was with…

This study tests whether analyzing the genes of a patient's tumor can help doctors choose a more effective treatment. Over 6,400 adults with advanced solid tumors, lymphomas, or multiple myeloma that have not responded to standard therapy are enrolled. The goal is to see if targe…

This study looked at whether regular screening tests for prostate, lung, colorectal, and ovarian cancers can help find cancer early and reduce deaths from these diseases. Over 154,000 people aged 55 to 74 took part. Researchers compared cancer deaths between those who got screene…

This study looks at whether system-level care coordination can improve how often people complete follow-up after lung cancer screening. It involves about 6,700 current or former smokers aged 50-80. The goal is to see if better tracking, direct communication, and support can incre…

This study looks at whether a 12-week virtual exercise program with group counseling can change gut bacteria and reduce inflammation in smokers at high risk for lung cancer. About 65 people aged 50-77 who smoke or used to smoke will take part. The goal is to see if this approach …

This study tests a web-based education tool called HOPE-Genomics that helps cancer patients learn about their genetic test results. About 465 adults with certain cancers (breast, lung, colorectal, and others) will use the tool to see if it improves their understanding of genomics…

This study looks at what happens when older smokers (ages 50-80) who are at high risk for lung cancer switch from regular cigarettes to e-cigarettes. Researchers will track how many cigarettes they smoke and measure health markers like inflammation in the blood. The goal is to he…

This study looks at two methods of collecting tissue samples from lymph nodes in people with suspected lung cancer. During a standard procedure called EBUS-TBNA, doctors sometimes use suction to help gather more material. The trial will compare samples taken with and without suct…

This study looks at how canakinumab, a drug that reduces inflammation, affects cells in the mouth, nose, and blood of former smokers who are at high risk for lung cancer. The goal is to see if blocking a specific inflammatory protein can slow or prevent cancer growth. About 41 pa…