HYPERPIGMENTATION

This study tested seven different cosmetic creams to see if they could prevent skin darkening caused by high-energy visible light (like from the sun or screens). 33 healthy adults with fair to medium skin had creams applied to their back before being exposed to a specific blue-vi…

This study tests whether a daily fizzy drink containing glutathione can safely lighten facial dark spots and improve skin radiance. Sixty adults with hyperpigmentation will take either the active drink or a placebo for several weeks. Researchers will measure changes in pigmentati…

This large-scale trial is testing whether a topical cream containing epigallocatechin gallate (EGCG), a compound from green tea, can reduce facial redness (erythema), dark spots (melanin), and improve skin moisture. Over 300 participants will apply the cream twice daily for 84 da…

This trial tests whether a topical chemical skin biostimulator containing homocysteic acid can improve firmness, wrinkles, texture, and hydration in women aged 39–69 with sun-damaged skin. Twenty-five women receive four treatment sessions two weeks apart, followed by a home-care …

This 4-week pilot study tested two brightening serums against 4% hydroquinone in 18 adults with hyperpigmentation or melasma. Each participant used different products on each side of their face to compare results. The goal was to see if the serums could improve skin tone evenness…

This completed study tested a brightening treatment (a type of chemical peel) combined with a retinol serum and post-procedure cream on 11 healthy women aged 20 to 65 with moderate facial pigmentation from sun exposure or blemishes. Participants received four treatment sessions t…

This study tested a dark spot corrector serum along with two different skincare routines in 48 women with moderate age spots. Over 16 weeks, doctors checked if the spots got lighter, smaller, or less noticeable. The goal was to see if the treatment was safe and effective for impr…

This study tested a special laser (1927nm) to reduce dark spots on the face in 15 adults with Fitzpatrick Skin Types V and VI (darker skin). The goal was to see if the laser works and to find the best skin care routine before and after treatment to avoid side effects like scarrin…