HEMATOLOGIC DISEASES

This study tests whether adding the drug vorinostat to standard care can prevent graft-versus-host disease (GVHD) in children, adolescents, and young adults receiving a bone marrow or blood stem cell transplant for blood cancers or disorders. About 43 participants will receive vo…

This study was designed to test an experimental drug called HMPL-523 in adults with immune thrombocytopenia (ITP), a condition where the immune system destroys platelets, causing bleeding problems. The goal was to see if the drug is safe and can raise platelet counts. However, th…

This study tests a one-time gene-editing treatment (CTX001) in 16 children with transfusion-dependent beta-thalassemia, a severe blood disorder. The therapy uses the child's own stem cells, modified with CRISPR-Cas9, to produce healthy red blood cells. The main goal is to see if …

This study follows 160 children and adults with beta-thalassemia or sickle cell disease who received a one-time treatment of their own CRISPR-edited stem cells (CTX001). Researchers will monitor participants for years to check for side effects, new cancers, and how well the thera…

This study follows over 32,000 people who helped clean up the 2010 Deepwater Horizon oil spill in the Gulf of Mexico. Researchers want to see if exposure to oil and chemicals during cleanup leads to long-term health problems like heart disease, cancer, or lung issues. Participant…

This study gathers medical records, test results, and treatment information from up to 10,000 people with various blood and heart conditions, as well as stem cell donors. The goal is to create a large database that researchers can use to develop new ideas for future studies. Part…

This early study tests whether frozen testicular tissue can be grafted back into men to produce sperm. It involves 5 men aged 40 or older who are having routine groin surgery. The goal is to see if this approach could one day help boys and men who lose fertility due to cancer tre…

This study collects tissue samples from people receiving bone marrow transplants and their donors. Researchers will analyze these samples to identify genes and proteins that may play a role in cancer development and progression. The goal is to better understand transplant outcome…

This study looks at how blood cancers and stem cell transplants impact muscle function in 144 patients. Researchers want to see if muscle problems can help predict complications like infections, hospital stays, or survival. The goal is to better understand recovery and guide futu…

This study tests a new digital tool that helps hospitals share patient information more reliably when a person is transferred from one hospital to another. The goal is to reduce medical mistakes and improve safety. About 1,000 adults being transferred to a major hospital will tak…