HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)
Clinical trials for HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF) explained in plain language.
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New tool aims to help heart failure patients get the right meds
Disease control Not yet recruitingThis study tests a web-based tool called SHARE-HF that helps heart failure patients and their doctors make medication decisions together. The tool shows personalized prognosis and medication options. Researchers will compare clinics using the tool to those with usual care, involv…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)
Phase: NA • Sponsor: University of British Columbia • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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New pill could help failing hearts pump better
Disease control Not yet recruitingThis study tests an experimental oral drug called AC01 in 400 people with chronic advanced heart failure and a weak heart pump. The goal is to see if AC01 can safely improve heart function over 12 weeks compared to a placebo. Participants will have heart ultrasounds and blood tes…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)
Phase: PHASE2 • Sponsor: AnaCardio AB • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Heart shunt device aims to boost energy in failing hearts
Disease control Not yet recruitingThis study tests a small device called an interatrial shunt that is placed in the heart to relieve pressure. It involves 15 adults with advanced heart failure and reduced pumping ability. Researchers will use advanced heart scans and exercise tests to see if the device improves h…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)
Phase: NA • Sponsor: Heinrich-Heine University, Duesseldorf • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Can quick drug optimization after heart failure hospitalization save lives in women?
Disease control Not yet recruitingThis study tests whether quickly starting and increasing guideline-recommended heart failure medications after hospitalization improves outcomes in women. About 360 women from 13 Italian hospitals will be randomly assigned to either a high-intensity care group (rapid drug optimiz…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)
Phase: PHASE4 • Sponsor: IRCCS Policlinico S. Donato • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Could zapping a nerve ease heart failure? new trial tests it
Disease control Not yet recruitingThis early-stage trial tests whether a catheter-based procedure that zaps a nerve near the spine can safely help people with heart failure with reduced ejection fraction. Up to 50 patients will be randomly assigned to get the real treatment or a sham procedure, and neither they n…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)
Phase: NA • Sponsor: Axon Therapies, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Olive oil may boost heart rehab for heart failure patients
Symptom relief Not yet recruitingThis study tests whether taking at least 4 tablespoons of extra-virgin olive oil daily for 12 weeks, alongside standard cardiac rehab, is feasible and helpful for people with heart failure with reduced ejection fraction. Researchers will measure changes in diet, exercise capacity…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)
Phase: NA • Sponsor: Old Dominion University • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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New study aims to decode heart failure using body data
Knowledge-focused Not yet recruitingThis study looks at 600 people (400 with chronic heart failure and 200 healthy) to find patterns in genes, proteins, and gut bacteria that may predict who gets worse. Researchers will track patients for one year to see who is hospitalized or dies. The goal is to create a better r…
Matched conditions: HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF)
Sponsor: Xinjiang Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC