HARM REDUCTION

This study looks at whether e-cigarettes or a medicine called cytisine can help people who still smoke at least 5 cigarettes a day even after trying nicotine patches, gum, or counseling. Over 4 years, 6,000 participants will be randomly given either an e-cigarette starter kit or …

This study will test a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risk. About 200,000 patients will be involved, and researchers will compare …

This study tests whether a computer alert that reminds doctors about treatment options can increase the use of medications for opioid use disorder. About 200,000 patients will be involved, with some doctors getting the alert and others not. The goal is to see if the alert leads t…

This study will test if a technology-based tool (like an app with videos and rewards) is helpful and easy to use for people living in supportive housing who also have substance use issues. About 25 residents and staff will try the tool for two weeks. Researchers want to see if it…

This study tests a computer alert that notifies doctors when a patient is about to move into a new phase of opioid therapy (like from short-term to long-term use). The goal is to help doctors pause and check if the opioid is still needed, reducing the risk of addiction or overdos…