GASTROINTESTINAL DISEASES

This study tests a new medicine, PF-08634404, combined with standard chemotherapy for people with colorectal cancer that has spread. About 800 adults who have not had prior treatment for metastatic disease will be randomly assigned to receive either the new drug or an approved dr…

This study is testing a new surgical stapler (Signia™) used to reconnect the colon after part of it is removed. The main goal is to see how often leaks happen at the connection site. About 137 adults having planned left-sided colon or rectal surgery will take part.

This study is the first time IDRX-42 is being tested in people. It aims to find out if the drug is safe and can shrink tumors in adults with advanced GIST that has spread or cannot be removed by surgery. Participants must have already tried the standard treatment imatinib without…

This study is testing whether transferring healthy bacteria from donor stool into the gut can reduce stomach issues, autism-related behaviors, and emotional problems in people with autism spectrum disorder (ASD) who also have gastrointestinal symptoms. About 60 participants aged …

This study tests if using virtual reality (VR) can improve symptoms of non-cardiac chest pain, which is chest pain not caused by the heart. Ten adults with this condition will try VR sessions, and researchers will measure changes in pain, anxiety, and quality of life. The goal is…

This study tests whether a daily supplement called Skål Pro (containing a friendly bacteria and a prebiotic fiber) can reduce belly pain, bloating, and irregular bowel movements in people with irritable bowel syndrome (IBS). About 60 adults with IBS will take either the supplemen…

This study looks at the bacteria and other microbes present in leaks that occur in the esophagus or stomach after surgery or injury. Researchers want to understand how these microbes change over time and how the body responds, with the goal of finding ways to help leaks heal fast…

This study is testing a new, ultra-thin endoscope that can be used without sedation to examine the upper digestive tract in people being treated for obesity. The goal is to see if this approach is more comfortable and convenient than traditional endoscopy, which usually requires …

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…