ESOPHAGUS CANCER

This study looks at whether adding immunotherapy or targeted drugs to standard chemoradiotherapy can help people with esophageal or esophagogastric junction cancer live longer. It involves 2,000 adults with stage I to IVa cancer who are not able to have surgery. The goal is to fi…

This study tests whether a special vacuum device placed inside the body can prevent dangerous leaks where the esophagus is reconnected to the stomach after cancer surgery. About 44 adults having minimally invasive esophageal cancer surgery will receive this preventive treatment. …

This study tests a new drug called ivonescimab combined with standard chemotherapy (FOLFOX) in people with advanced HER2-negative stomach or esophagus cancer that has not been treated before. The goal is to see if the combination can stop the cancer from growing for at least 6 mo…

This study tests a new way of giving chemotherapy to people with advanced gastrointestinal cancers, like colorectal or stomach cancer. The approach adjusts the dose of one chemo drug (5-FU) based on how well each patient tolerates the initial dose, aiming to give a stronger, more…

This study tests whether combining two drugs, afatinib and palbociclib, can help people with advanced esophageal cancer that has come back or spread after prior treatment. About 45 adults aged 18 to 75 will take part. The goal is to find a safe dose and see if the combination shr…

This early-phase trial tests a new drug (CA-4948) combined with standard chemotherapy and immunotherapy for people with advanced stomach, esophageal, or gastroesophageal junction cancer that cannot be removed by surgery. The study aims to find the safest dose and check if the com…

This study is testing a new type of PET/CT imaging that uses special probes to target and highlight digestive system cancers, including cancers of the liver, stomach, colon, pancreas, and more. Researchers want to see how these probes spread in the body and how well they can find…

This study tests whether using virtual reality (VR) can reduce severe belly pain in people with digestive tract cancers. 360 participants will be split into three groups: one using skills-based VR, one using distraction VR, and a sham control group. Researchers will track pain, a…

This study uses artificial intelligence to analyze patient data—like scans, lab results, and medical history—to predict how well esophageal cancer responds to chemotherapy and immunotherapy before surgery. Researchers aim to identify which patients achieve a complete response and…

This study is collecting information from 8,000 cancer patients treated with a special machine called the MR-Linac, which combines an MRI scanner with a radiation therapy device. The goal is to see how well this technology works for different cancers, including breast, prostate, …

This study is testing a new questionnaire to better understand and track symptoms in people with upper digestive diseases or who have had esophageal surgery. Researchers will ask 1000 patients to complete the survey at different times. The goal is to create a standard tool that h…

This study reviews the medical records of about 4000 people who had surgery for esophageal cancer. The goal is to see how the edge of the removed tissue (called the margin) relates to how long patients live and whether the cancer comes back. No new treatments or procedures are gi…