ESOPHAGUS CANCER

This large study aims to find the best treatment combination for patients with esophageal or stomach junction cancer that cannot be surgically removed. Researchers will test whether adding newer immunotherapy drugs or targeted therapies to standard chemotherapy and radiation impr…

This study is testing whether adding a new drug called ivonescimab to standard chemotherapy (FOLFOX) works better for people with advanced stomach or esophagus cancer that is HER2-negative. The goal is to see if this combination can help control the cancer for longer and shrink t…

This study is testing whether combining two existing drugs, afatinib and palbociclib, can help control advanced esophageal cancer that has come back or spread after prior treatment. The first part of the trial will find a safe dose, and the second part will see if the combination…

This early-stage trial is testing a new drug called CA-4948 in combination with standard chemotherapy and immunotherapy for people with advanced stomach or esophageal cancer that cannot be surgically removed. The study aims to find the safest dose of this combination and see if i…

This study is testing a new approach to chemotherapy for advanced gastrointestinal cancers. It aims to see if doctors can safely increase the dose of a key chemo drug for patients who tolerate the standard dose well. The goal is to see if this personalized, higher-dose approach i…

This study is testing new radioactive tracer chemicals for PET/CT scans to see if they can better detect and monitor cancers of the digestive system, including stomach, colon, liver, and pancreatic cancer. About 400 adults with confirmed or suspected digestive cancer will receive…

This study is testing if a special vacuum sponge can prevent a dangerous complication called an anastomotic leak after surgery for esophageal cancer. The sponge is placed inside the patient where the stomach and esophagus are reconnected and applies gentle suction. Researchers wi…

This study is testing whether virtual reality (VR) can help reduce pain and improve quality of life for people with gastrointestinal cancers. Researchers will compare three approaches: VR that teaches pain management skills, VR designed to distract from pain, and a basic VR contr…

This study examines past medical records of 4,000 people who had surgery for esophageal cancer. Researchers want to understand how different surgical approaches and treatment timing affect long-term survival. The goal is to learn from historical data to improve future cancer care…

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study aims to see if artificial intelligence (AI) can predict how well a patient's esophageal cancer will respond to drug treatment before they have surgery. Researchers will use information from 200 patients, including their medical history, scans, and lab tests, to train t…