ESOPHAGEAL CANCER

This phase 3 trial tests whether adding two drugs—toripalimab (an immunotherapy) and capecitabine (a chemotherapy pill)—after standard chemoradiation can help prevent esophageal cancer from coming back. About 242 adults with advanced esophageal cancer that hasn't spread after ini…

This study tests a new treatment that delivers a powerful, short-range radioactive particle directly to cancer cells that have a protein called FAP on their surface. The therapy is given in two steps: first a low-dose imaging version to see if the tumor takes up the drug, then a …

This study is testing a new blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will enroll 7,000 people to see if the test can find cancer early, detect any cancer left after treatment, and spot a relapse before …

This study is testing whether a personalized program of naturopathic care, Mediterranean diet, and physical activity before and after surgery can improve quality of life and reduce complications for people with lung, stomach, or esophageal cancer. About 20 adults scheduled for cu…

This study collects tissue and blood samples from people with stomach or esophageal cancer, as well as those at high inherited risk, to learn how genes and proteins contribute to these cancers. Researchers aim to better understand the disease, not to test a new treatment. About 1…

This study is for people with certain advanced cancers (like lung, head and neck, or esophageal cancer) who are already scheduled to receive immunotherapy (PD-1/PD-L1 inhibitors). Researchers want to see if adding radiation therapy improves outcomes and, more importantly, if chan…

This study collects tissue, blood, urine, and stool samples from 5,000 people undergoing colonoscopy or endoscopy. Researchers want to find new biomarkers that could help detect colorectal, esophageal, stomach, and pancreatic cancers earlier. Participants include both healthy vol…

This study is a large registry that will follow 8,000 cancer patients who receive radiation therapy using a special machine called the MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to see if this technology improves survival, tumor control, and qualit…