DIFFUSE MIDLINE GLIOMA
Clinical trials for DIFFUSE MIDLINE GLIOMA explained in plain language.
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Custom DNA vaccine targets Kids' brain tumors in early trial
⭐️ VACCINE ⭐️ Recruiting nowThis study tests a personalized DNA vaccine for children and young adults (ages 12-25) with central nervous system tumors that have come back or not responded to treatment. The vaccine is made from each patient's unique tumor DNA to train the immune system to fight the cancer. Th…
Matched conditions: DIFFUSE MIDLINE GLIOMA
Phase: PHASE1 • Sponsor: Washington University School of Medicine • Aim: ⭐️ VACCINE ⭐️
Last updated Jun 27, 2026 12:30 UTC
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New combo therapy aims to fight aggressive brain tumors in kids
Disease control Recruiting nowThis study tests a combination of a vaccine targeting the CMV virus (PEP-CMV) and an immunotherapy drug (nivolumab) in children and young adults with certain aggressive brain tumors, including diffuse midline glioma and medulloblastoma. The goal is to see if this approach is safe…
Matched conditions: DIFFUSE MIDLINE GLIOMA
Phase: PHASE1, PHASE2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Engineered immune cells delivered directly to the brain show promise for kids with deadly tumors
Disease control Recruiting nowThis early-stage trial tests a new treatment for children and young adults up to age 21 with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a pro…
Matched conditions: DIFFUSE MIDLINE GLIOMA
Phase: PHASE1 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Engineered immune cells take aim at childhood brain cancers
Disease control Recruiting nowThis early-phase study tests whether a new type of immunotherapy, called B7-H3 CAR T cells, can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG, DMG, or other recurrent central nervous system cancers. The…
Matched conditions: DIFFUSE MIDLINE GLIOMA
Phase: PHASE1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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New hope for kids with brain cancer? LAM561 trial launches
Disease control Recruiting nowThis study tests an oral drug called LAM561 in children under 18 with advanced brain tumors (like high-grade glioma) or other solid tumors that have not responded to standard treatments. The trial has two phases: first, finding a safe dose in up to 18 children, then testing that …
Matched conditions: DIFFUSE MIDLINE GLIOMA
Phase: PHASE1, PHASE2 • Sponsor: Laminar Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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New imaging test may help doctors spot real tumor growth in kids with brain cancer
Diagnosis Recruiting nowThis study tests whether a special PET scan called 18F-Fluciclovine can help doctors tell the difference between actual tumor growth and harmless changes caused by treatment in children with high-grade glioma. About 30 children aged 1 to 21 will receive the scan after radiation t…
Matched conditions: DIFFUSE MIDLINE GLIOMA
Phase: EARLY_PHASE1 • Sponsor: Children's Hospital of Philadelphia • Aim: Diagnosis
Last updated Jun 27, 2026 08:01 UTC
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Worldwide effort to crack the code of deadly childhood brain tumors
Knowledge-focused Recruiting nowThis study creates a central registry and tissue bank for people with DIPG or DMG, rare and aggressive brain tumors. Researchers will collect medical information, scans, and tumor samples from up to 1,500 patients of any age. The goal is to understand the biology of these tumors …
Matched conditions: DIFFUSE MIDLINE GLIOMA
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC