CHRONIC MYELOGENOUS LEUKEMIA

This study tested a treatment strategy for newly diagnosed chronic myeloid leukemia. Researchers wanted to see if patients who responded well to an initial strong drug (nilotinib) could switch to a cheaper, easier-to-use drug (imatinib) to maintain that response long-term. The go…

This study tested whether patients with a specific type of chronic leukemia could safely stop their daily medication, nilotinib, after it had successfully controlled their disease for a long time. It involved 215 adults whose cancer was in a stable phase and who had achieved a ve…

This study tested a pill called asciminib for adults with chronic-phase chronic myeloid leukemia (CML) who had already tried at least two other standard treatments and either didn't respond well or couldn't tolerate them. The main goal was to find the best daily dose and schedule…

This study tested the safety of swapping out one drug (cyclophosphamide) for another (bendamustine) in the days following a bone marrow transplant. It involved 50 patients with various blood cancers who needed a transplant but lacked a perfectly matched donor. The goal was to see…

This study tested whether adding a new drug called asciminib to the standard treatment imatinib could help patients with chronic myeloid leukemia (CML) achieve a deeper level of disease control. It involved 104 adults whose CML was not fully controlled by imatinib alone. Particip…

This study tested a less intense bone marrow transplant procedure for adults with various blood cancers who needed a transplant but did not have a fully matched donor. It used stem cells from a half-matched family member (like a parent, child, or sibling) after a milder pre-trans…