CERVICAL INTRAEPITHELIAL NEOPLASIA

This trial tested a new therapy for cancers caused by HPV-16, such as cervical, anal, and throat cancers. Researchers took patients' white blood cells, genetically engineered them to recognize a protein called E7 found in HPV cancer cells, and infused them back. Patients also rec…

This study tested whether a gel called Papilocare can help repair cervical lesions caused by HPV. About 200 women aged 30 to 65 with mild cervical changes used either Papilocare or a lactic acid gel for 6 months. The goal was to see if the gel could clear the lesions and the viru…

This study tested whether a vaginal gel called DEFLAGYN, made from silica and citric acid, can help women with unclear cervical smears and high-risk HPV infections clear the virus and avoid surgery. 242 women used the gel for 3 months. The goal was to see if the gel increases the…

This study tested whether women aged 50 to 65 can collect their own samples for HPV testing to screen for cervical cancer. About 500 women in Cameroon participated. Those who tested positive for HPV then had a Pap smear and other exams to check for precancerous changes. The goal …

This study tested a liquid-based Pap smear (ThinPrep) to screen 984 Egyptian women aged 25–60 for early signs of cervical cancer during routine gynecology visits. The goal was to see if this method could detect abnormal cells more effectively than standard approaches. Results wil…

This study looked at how certain enzymes called matrix metalloproteinases (MMPs) and their inhibitors relate to human papillomavirus (HPV) in cervical dysplasia and cancer. Researchers collected tissue and cell samples from 216 women with different stages of cervical lesions. The…

This study looked at 50 women aged 30–50 who had a cervical conization (a cone-shaped biopsy) to treat abnormal cervical cells. Researchers measured blood flow in the uterine artery before and one month after surgery using Doppler ultrasound. The goal was to see if the surgery ch…

This study looked at 107 women having a first-time cervical procedure (LEEP) for abnormal cells. Researchers compared how local anesthesia (cervical block) versus general or spinal anesthesia affected the size of the removed tissue. The goal was to see if the anesthesia method in…

This study looked at whether giving women a self-collection kit for HPV testing at their family doctor's office would encourage more women to get screened for cervical cancer. The study involved 308 women aged 30-65 who were overdue for screening. Some women were offered the usua…

This study followed over 46,000 women in the Netherlands who tested positive for HPV and had mild abnormal Pap results. Researchers tracked how many developed cervical cancer within five years. The goal was to see if these women could safely have fewer follow-up tests, making scr…