CARDIOMYOPATHY

This study looks at how well a drug called mavacamten works for adults in Japan who have a heart condition that blocks blood flow (obstructive hypertrophic cardiomyopathy) and are already taking another drug, cibenzoline. About 36 people will join to see if the combination improv…

This early-stage study tests whether stem cells from a healthy donor can help control heart failure in people whose hearts were weakened by anthracycline chemotherapy. About 72 adults with a low heart pumping ability (LVEF 40% or less) will receive either standard care alone or s…

This study compares two common heart failure medications, carvedilol and metoprolol, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol. The goal…

This study tests artificial intelligence (AI) programs that help doctors interpret heart ultrasound images (echocardiograms). The goal is to see if the AI makes it easier and faster to diagnose specific heart conditions like genetic cardiomyopathy, blocked arteries, and cardiac a…

This study tests whether exercising in a community or home setting can improve exercise ability and quality of life for adults aged 18–85 with reduced heart or lung function. Two hundred participants will do 40–60 minutes of exercise five times a week for eight weeks, choosing ac…

This study is testing a new, detailed MRI scan to see if it can better detect and understand different heart problems, like heart attacks, heart muscle diseases, and valve issues. Researchers will scan 2,000 adults with known or suspected heart disease and track their health over…

This study aims to understand how different types of changes in the DMD gene are linked to heart problems in boys and young men with Duchenne or Becker muscular dystrophy. Researchers will use heart tests and blood samples to look for early signs of heart issues. The study involv…

This study tests a new paddle-shaped catheter designed to map heart rhythm problems like atrial fibrillation and ventricular tachycardia. About 60 people who need a standard heart mapping procedure will use this catheter. The goal is to check if it is safe and can successfully ma…

This study aims to understand how heart disease develops and progresses in people with Friedreich ataxia, a rare genetic condition. Researchers will monitor 65 participants aged 6 and older using heart imaging over time. The goal is to gather detailed information that could help …

This study is for breast cancer patients receiving certain chemotherapies that can harm the heart. Researchers want to see if a genetic marker called TRPC6 can predict who will develop heart problems. By analyzing blood samples, they hope to find early warning signs and ways to p…

This study looks at whether certain genes make some people more likely to develop a weak heart muscle (cardiomyopathy) from atrial fibrillation (AF). Researchers will compare the DNA of 299 adults with AF who had heart recovery, those who didn't, and healthy controls. The goal is…

This study is for people with light chain amyloidosis, a rare disease where abnormal proteins build up in the heart and other organs. Researchers will use special PET and MRI scans to take detailed pictures of these protein deposits in the heart. The goal is to better understand …

This study checks if two different versions of HRS-1893 tablets are absorbed the same way in the body. It involves 36 healthy adults aged 18 to 55. The main goal is to measure drug levels in the blood and watch for any side effects. This is an early-stage study, so it does not of…

This study aims to find the genetic causes of inherited heart conditions like cardiomyopathy and arrhythmia, as well as muscular dystrophy. Researchers will analyze DNA from patients and their families to identify disease-related genes. The study is open to people of all ages, es…

This study aims to better understand heart and blood vessel diseases by observing people who have them or are at risk, as well as their relatives and healthy volunteers. Researchers will collect samples and perform tests like imaging and heart function assessments. No treatment i…