BRONCHOPULMONARY DYSPLASIA (BPD)

This study tests whether keeping very preterm babies on CPAP (a breathing machine) until 34 weeks after conception, instead of switching to a nasal cannula, reduces their risk of bronchopulmonary dysplasia (a chronic lung disease) or death. About 860 infants born before 29 weeks …

This study compares transfusions using red blood cells from umbilical cord blood versus standard adult donor blood in extremely premature infants. About 176 babies born before 28 weeks or weighing under 1000 grams will be enrolled. The goal is to see if cord blood reduces the ris…

This study tests whether giving the steroid betamethasone to extremely premature babies (born before 28 weeks) helps them come off breathing machines more easily and lowers their risk of chronic lung disease. About 100 babies will receive either standard NICU care plus betamethas…

This study compares two types of high-frequency ventilators for premature babies born before 32 weeks who have breathing problems. The new mode, HFOV-VG, aims to deliver more stable breaths to reduce lung injury. Researchers will see if it lowers the chance of severe chronic lung…

This study tests two different ways of giving the steroid dexamethasone to very premature babies (born before 30 weeks) who have been on a breathing machine for at least two weeks. The goal is to see which treatment better prevents a serious lung condition called bronchopulmonary…

This observational study will look at how often very low birth weight babies in Canadian NICUs get ventilator-associated pneumonia (VAP) and how these infections are treated. Researchers will compare different hospitals' approaches to diagnosis and care, with the goal of creating…

This study looks at 40 premature babies (born before 30 weeks) to see if viruses in their lungs and gut during the first three weeks of life are linked to a serious lung condition called bronchopulmonary dysplasia (BPD). Researchers will collect throat and stool samples to track …