BRCA1 MUTATION

This study is testing if adding a newer drug called elacestrant to the standard treatment olaparib works better for controlling advanced breast cancer in people with specific BRCA gene mutations. About 176 participants will be randomly assigned to receive either the two-drug comb…

This study is testing a new oral drug called ETX-19477 in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find a safe dose and see if the drug can help control the cancer. Researchers are especially interested in enroll…

This is an early-stage study to find a safe and tolerable dose of two oral drugs, olaparib and ASTX727, when given together. It is for adults with advanced solid tumors that have specific mutations in genes like BRCA1, BRCA2, PALB2, ATM, or CHEK2. The main goals are to check for …

This early-stage trial is testing a new treatment for people with metastatic pancreatic or breast cancer. The goal is to see if a combination of high-dose chemotherapy drugs, vitamins, and the patient's own stem cells is safe and can overcome the cancer's resistance to treatment.…

This study is testing a new oral drug called ACE-86225106 to see if it is safe and can help control advanced solid tumors in adults. It is for people with cancers like ovarian, breast, or prostate cancer that have not responded well to standard treatments. The main goals are to f…

This study is testing if taking a targeted pill called olaparib, along with hormone therapy, for 6 months before prostate removal surgery helps men with high-risk prostate cancer. It is for men whose cancer has specific genetic changes. The main goal is to see if this pre-surgery…

This early-stage study aims to find a safe and effective dose for combining two cancer drugs, niraparib and irinotecan. It is for adults with advanced solid tumors (like certain breast, ovarian, or pancreatic cancers) that have spread and have specific mutations in genes like BRC…

This study tests whether an online support program helps family members of people with BRCA gene mutations get tested more easily than the usual clinic-based process. It involves a patient navigator, an educational video, and a free at-home saliva test kit. The goal is to identif…

This study aims to create a large collection of blood samples from cancer patients and people at high risk for cancer. Researchers will use these samples to build a research library for future studies on 'liquid biopsies'—blood tests that can detect cancer DNA. The goal is to hel…

This study aims to gather detailed health information from 10,000 Italian women who carry BRCA1 or BRCA2 gene mutations, which increase cancer risk. Researchers will track participants over time to better understand how these mutations lead to cancer and to improve prevention and…

This study is testing a new educational video to help people with BRCA gene mutations make more informed decisions about hormone replacement therapy (HRT) after having their ovaries and fallopian tubes removed to prevent cancer. Researchers will compare the video plus standard co…

This study is testing two new digital approaches to improve cancer genetic counseling. The first part helps doctors contact family members of a patient with a cancer gene to encourage them to get tested. The second part helps patients and their doctors stay updated when a genetic…