AORTIC REGURGITATION
Clinical trials for AORTIC REGURGITATION explained in plain language.
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New heart valve shows promise in large trial
Disease control OngoingThis study is testing a new surgical heart valve (Model 400) in over 1,300 people with aortic valve disease. The valve is designed to replace the damaged aortic valve and improve blood flow. Researchers are checking how safe the valve is and how well it works over one year, looki…
Matched conditions: AORTIC REGURGITATION
Phase: NA • Sponsor: Medtronic Cardiac Surgery • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Less invasive heart valve replacement may be better for seniors with small valves
Disease control OngoingThis study compares two ways to replace a narrowed heart valve in elderly patients (65+) who have a small valve opening. One method is less invasive (TAVR, through a tube in an artery), the other is open-heart surgery. The goal is to see which approach gives better blood flow and…
Matched conditions: AORTIC REGURGITATION
Phase: NA • Sponsor: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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3D tech may sharpen heart valve placement in leaky aortic disease
Disease control ENROLLING_BY_INVITATIONThis study tests whether using 3D simulation before a minimally invasive aortic valve replacement helps doctors place the valve more accurately. It involves 354 adults aged 65 and older with severe aortic regurgitation (a leaky heart valve). Participants are randomly assigned to …
Matched conditions: AORTIC REGURGITATION
Phase: NA • Sponsor: Xijing Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Heart MRI could predict when valve patients need surgery
Knowledge-focused OngoingThis study looks at whether a special MRI scan can detect early scarring in the heart muscle of people with leaky heart valves. The goal is to find a way to predict when the heart might start to fail, so doctors can decide on surgery sooner. About 316 adults with moderate to seve…
Matched conditions: AORTIC REGURGITATION
Phase: NA • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC