ALZHEIMER DISEASE (AD)

This study tests whether taking silkworm pupa powder daily for four months can improve thinking, daily living, and nutrition in people with Alzheimer's disease. About 300 participants will receive either the powder or a placebo. Researchers will track changes in memory, frailty, …

This study tests whether infusions of cells from umbilical cord blood can help people with mild to moderate Alzheimer's disease. Thirty participants will receive either a low dose, high dose, or a placebo (salt water) through an IV once a week for four weeks, plus a fifth dose a …

This study tests if the drug levetiracetam can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and possibly slow brai…

This study tests whether daridorexant, a sleep medication, can help the brain clear proteins linked to Alzheimer's disease. The trial includes 240 adults without dementia, regardless of sleep issues. Participants take the drug or a placebo nightly for one year, and researchers me…

This study explores whether rhythmic auditory stimulation (like a metronome beat) can improve walking and brain function in people with Alzheimer's disease or mild cognitive impairment. Participants will walk while listening to rhythmic sounds, and researchers will measure change…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study is creating a new computer-based cognitive assessment to help detect Alzheimer's disease in its earliest stages. Researchers are working with memory nurses and older adults to design the test and a training course for nurses. 120 older adults with memory concerns will …

This observational study is testing a new model that combines genetic data, blood tests, and digital monitoring (like sleep and activity trackers) to predict early memory decline in adults aged 55 and older who carry the ApoE4 gene variant. Researchers will follow 100 participant…

This study looks at whether people with Alzheimer's disease have lower levels of a natural chemical called NAD in their brains compared to healthy older adults. Researchers will use a special MRI scan to measure NAD in 20 volunteers aged 65 to 80. Participants will have two scans…

This study follows 1,573 adults aged 50 to 90 across Canada, including people with different types of dementia and those with healthy memory. Researchers will use memory tests, brain scans, and blood samples to track how thinking and memory change over time. The goal is to better…