Vascular malformation

This phase 2 trial tests the drug trametinib in 45 people aged 2 months to 30 years with vascular anomalies caused by changes in the Ras/MAPK pathway. Participants take trametinib daily for up to 3 years. The study measures whether the drug shrinks lesions, improves quality of li…

This study tests the drug alpelisib, already approved for some breast cancers, in people aged 2 months to 30 years with certain blood vessel growth disorders caused by PIK3CA or TIE2 gene changes. Participants take the drug for 2-3 years and attend up to 16 clinic visits to check…

This phase 3 trial is testing a gel containing rapamycin (QTORIN 3.9%) for people aged 3 and older with microcystic lymphatic malformations, a rare condition causing fluid-filled bumps on the skin. About 40 participants will apply the gel daily for 24 weeks to see if it improves …

This study uses a special camera and a safe dye to take pictures of the lymphatic system, which helps move fluid in the body. Researchers want to see how this system works in healthy people and in those with conditions like lymphedema or lipedema. The goal is to find patterns tha…

Slow-flow vascular malformations — abnormal clusters of veins, capillaries, or lymph vessels — can cause pain, swelling, and appearance concerns. This study follows 60 children and adults who receive bleomycin electrosclerotherapy (BEST), a procedure that injects the drug bleomyc…

This study is observing 328 adults who receive a Neuro-Patch during brain or spine surgery to repair the protective lining around the brain or spinal cord. Researchers are tracking complications and how easy the patch is for surgeons to use. The goal is to gather real-world data …