Urinary bladder neoplasm

This study tests whether adding immunotherapy drugs (nivolumab, with or without BMS-986205) to standard chemotherapy before and after bladder cancer surgery helps more people achieve a complete response and live longer without the cancer returning. About 855 adults with muscle-in…

This early-phase trial tested two drugs—durvalumab and vicineum—in 15 people with high-grade non-muscle-invasive bladder cancer that had not responded to standard BCG treatment. The goal was to see if the combination is safe and can help the immune system fight the cancer. Partic…

This trial tests a modified surgical approach for removing bladder tumors that are 3 centimeters or larger. The technique first removes the outer part of the tumor in pieces, then removes the base in one piece. The goal is to see if this method leads to complete tumor removal and…

This phase 2 trial tested a combination of two drugs—TAR-200 (placed directly into the bladder) and cetrelimab (an immunotherapy given by IV)—in 163 people with muscle-invasive bladder cancer who were scheduled for bladder removal surgery and could not or would not take standard …

This study compared two surgical techniques for removing early-stage bladder tumors: a new laser method (holmium laser en-bloc resection) and the standard approach (conventional transurethral resection). 100 adults with suspected non-muscle-invasive bladder cancer were randomly a…

This phase 2 trial tested a daily pill called erdafitinib against standard chemotherapy for people with a high-risk bladder cancer that returned after BCG treatment. The study enrolled 107 participants whose tumors have specific FGFR gene changes. The goal was to see if erdafitin…

This study tested two surgical methods for removing early-stage bladder tumors that haven't spread to muscle. One method removes the tumor in one piece (en bloc), while the standard method removes it in multiple pieces. Researchers wanted to see if the one-piece method gives bett…

This study tested an experimental drug called ESG401 in 156 people with advanced solid tumors (including breast, lung, and colorectal cancers) who had no other treatment options. The goal was to check the drug's safety, find the right dose, and see if it could shrink tumors. The …

This study tested whether analyzing urine with a special light technique (spectroscopy) can accurately detect bladder cancer. Researchers collected urine samples from 899 people undergoing cystoscopy. The goal was to see if the light patterns could tell apart those with cancer fr…

This study tested whether a simple urine test (Xpert Bladder Cancer Detection Test) can accurately detect bladder cancer in people undergoing cystoscopy. Researchers enrolled 127 adults in Greenland, where access to urology services is limited. The goal was to see if the urine te…

This early-phase trial tested whether a nutritional supplement called Impact Advanced Recovery® could help men recover better after bladder cancer surgery. Thirty men took the drink before and after their operation. The goal was to see if it reduced surgical complications, infect…

This study tested two ways to numb the obturator nerve during bladder tumor surgery to prevent sudden leg muscle spasms that can cause complications. Sixty patients aged 50-80 were randomly assigned to receive either a single-injection or a two-injection nerve block. The goal was…

This study looked at 93 adults having bladder tumor surgery under spinal anesthesia. It compared two intravenous drugs—magnesium sulfate and dexmedetomidine—to see which better controlled pain after surgery. Magnesium sulfate led to lower pain scores, delayed the need for extra p…

This study tested a health cloud platform accessed via smartphone to help patients who have a urostomy after bladder cancer surgery. The platform allowed patients to check their medical info and communicate with nurses. Researchers measured whether this improved patients' ability…

This study compared penile length in 200 adult men undergoing cystoscopy under spinal anesthesia versus general anesthesia. Researchers measured length and asked surgeons to rate satisfaction with access. The goal was to see if anesthesia choice affects penile size during the pro…