Tuberculous fibrosis of lung

This trial is testing two tuberculosis (TB) vaccines—VPM1002 and a repeat BCG vaccination—in pre-adolescents aged 8-14 who were vaccinated at birth. The goal is to see if these vaccines are safe and trigger a strong immune response in children both with and without HIV, and in th…

This study is developing a new way to treat pulmonary fibrosis, a condition where the lungs become scarred and stiff. The approach uses tiny particles called liposomes, coated with hyaluronic acid, to deliver drugs directly to the cells that cause scarring. The research is being …

This study tests a fast point-of-care PCR test (Spotfire) that quickly identifies whether a respiratory infection is caused by a virus. The goal is to give ER doctors results faster so they can avoid prescribing antibiotics when they won't help. The trial enrolls 200 adults with …

This pilot study tests whether home-based or video-supervised exercise programs are acceptable and helpful for people with chronic lung diseases like IPF, sarcoidosis, bronchiectasis, asthma, and other interstitial lung diseases. Fifty participants will be randomly assigned to on…

This study tests whether low-intensity aerobic exercise with blood flow restriction (BFR) is safe and effective for people with interstitial lung disease (ILD). BFR uses a cuff to partially block blood flow, which may help build muscle with less strain. Thirty participants will t…

This study looks for biological markers in blood and lung samples from people with idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases. The goal is to find markers that can predict how the disease will progress and to group patients into subtypes. Researchers…

This study looks at whether air samplers placed in homes can detect viruses that cause colds and flu, and how that compares to standard nasal swabs. About 422 students and their families will participate. The goal is to better understand how respiratory viruses spread through hou…

This study looks at how things in the environment and at work might affect people with interstitial lung diseases (a group of lung conditions). Researchers will ask 1,000 adults with a new diagnosis about their exposures to things like pollution, chemicals, and dust. The goal is …

This study compares new, less invasive ways to collect samples for respiratory virus testing—like a nasal wash or saliva—against the standard deep nose swab. Researchers want to see if these gentler methods work just as well and cause less pain. About 1,000 adults in the emergenc…

This study places a rapid testing device in primary care clinics to help doctors quickly identify whether a cold-like illness is caused by a virus or bacteria. About 8,000 adults with symptoms like cough or runny nose will get a nasal swab, with results in 15 minutes. The goal is…

This study explores whether a special MRI scan using xenon gas can spot early signs of lung scarring and heart strain in people with progressive lung fibrosis. About 30 adults already on anti-fibrotic medication will be scanned and followed over time. The goal is to see if this i…