Spontaneous intracranial hypotension
MONDO:0018624Also known as: spontaneous cerebrospinal fluid leak
15 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Tailored therapy shows promise for teens with headaches
Symptom relief CompletedThis study tested a personalized psychological intervention for 5 adolescents aged 12-18 with recurrent headaches. Researchers used smartphone surveys to track each teen's unique headache triggers and coping patterns, then delivered 4-5 weekly online therapy sessions based on tha…
Phase: NA • Sponsor: Royal Holloway University • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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Eye ultrasound may reveal hidden brain pressure disorder
Knowledge-focused CompletedThis study looks at whether measuring the optic nerve sheath diameter—the lining around the nerve that connects the eye to the brain—using ultrasound can help doctors know if a treatment for spontaneous intracranial hypotension (a condition where low spinal fluid causes severe he…
Sponsor: Yonsei University • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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Hands-On therapy may rewire headache brains, pilot study shows
Knowledge-focused CompletedThis study looked at how osteopathic manual therapy (OMT) changes the brain in people with migraines, tension, or cluster headaches. Researchers used MRI scans to see if OMT affects brain structure and activity. The goal was to understand how OMT reduces pain and disability, not …
Phase: NA • Sponsor: Edward Via Virginia College of Osteopathic Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Blood protein may help ER spot serious headaches
Knowledge-focused CompletedThis study looked at whether measuring a protein called S100B in the blood can help emergency doctors tell the difference between primary headaches (like migraines) and secondary headaches (caused by something serious like a bleed or infection). Researchers enrolled 81 adults wit…
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Headaches linked to poor sleep and mental health in new study
Knowledge-focused CompletedThis study looked at how headaches impact sleep, pain sensitivity, and emotional well-being in 132 adults aged 18-65. Researchers measured sleep quality, central sensitization (a heightened pain state), and levels of depression, anxiety, and stress using standard questionnaires. …
Sponsor: Nagihan Acet • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC