Spondyloepimetaphyseal dysplasia, Missouri type

MONDO:0011198

A spondyloepimetaphyseal dysplasia characterized by moderate-to-severe metaphyseal changes, mild epiphyseal involvement, rhizomelic shortening of the lower limbs with bowing of the femora and/or tibiae, coxa vara, genu varum and pear-shaped vertebrae in childhood.

Also known as: SEMD type 2, SEMD, Missouri type, spondyloepimetaphyseal dysplasia type 2, spondyloepimetaphyseal dysplasia, Missouri type, Missouri type of spondyloepimetaphyseal dysplasia, SEMD Missouri type, metaphyseal anadysplasia 1, spondyloepimetaphyseal dysplasia Missouri type

35 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Musculoskeletal system disorder (196) Hereditary disease (172) Bone disorder (47) Human disease (14) Osteochondrodysplasia (12) Skeletal system disorder (4) Bone development disease (2) Disease of genetic or genomic mechanism (2) Skeletal dysplasia (1)

Trials to join now! 17 Not yet recruiting 6 Not yet finished but already full! 4 Completed 7 Terminated 1

Scientists gather leftover surgical tissue to unlock secrets of bone disease

Knowledge-focused Terminated

This study collected bone, cartilage, skin, and fat tissue from 50 patients undergoing surgery at Children's National Medical Center. The goal was to grow cells from these tissues in the lab and analyze them to better understand bone and connective tissue diseases. The study was …

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) • Aim: Knowledge-focused

Last updated Jun 27, 2026 07:52 UTC

Spondyloepimetaphyseal dysplasia, Missouri type

Broader categories

Scientists gather leftover surgical tissue to unlock secrets of bone disease