Small intestine adenocarcinoma

This phase II trial tests whether adding paclitaxel directly into the abdomen, alongside standard systemic chemotherapy, is feasible for people with gastrointestinal cancers that have spread to the peritoneal lining. The study includes patients with gastric, colorectal, appendice…

This phase II trial compares two chemotherapy combinations—ramucirumab plus paclitaxel versus FOLFIRI—in 94 patients with advanced or treatment-resistant small bowel adenocarcinoma. The goal is to see which regimen better slows cancer growth and extends survival. Participants mus…

This phase 2 trial tests a four-drug chemotherapy combination called NALIRIFOX in 36 adults with advanced small bowel adenocarcinoma that cannot be removed by surgery. The drugs are given intravenously on days 1 and 15 of each 28-day cycle for up to 6 cycles, followed by a milder…

This treatment program tests a personalized cell therapy for people with advanced pancreatic or colorectal cancers that have a specific genetic mutation (KRAS G12D). Patients' own immune cells are collected, genetically engineered to recognize and attack the cancer, and then infu…

This early-phase trial tests a two-step vaccine strategy in adults with advanced colorectal or small bowel cancer that has stopped responding to standard treatments. Participants first receive one vaccine injection, followed by two doses of a second vaccine four weeks apart. The …

This phase II trial tests enfortumab vedotin, a targeted drug that homes in on a protein called Nectin-4 found on many small bowel cancer cells. The study enrolls 27 adults whose cancer has worsened despite platinum-based chemotherapy or who cannot tolerate it. Participants recei…

This study tests a combination of three drugs (surufatinib, sintilimab, and capecitabine) in people with advanced small bowel or appendix cancer that has spread and stopped responding to standard treatments. The goal is to see if this mix can shrink tumors or slow cancer growth. …

This phase 2 trial is testing whether the immunotherapy drug dostarlimab can work better than standard chemotherapy as a first treatment for people with rare, advanced cancers that have a specific genetic flaw called dMMR/MSI. The study includes 120 adults with cancers like pancr…

This study is testing whether a swallowed video capsule (a pill-sized camera) can help find small bowel cancer early in people with Lynch syndrome, a genetic condition that raises cancer risk. About 100 participants will swallow a capsule every two years to take pictures of their…

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a pill-sized camera) to screen for pre-cancerous growths or cancer in the small intestine. The goal is to see how well this camera test finds these lesions compared …