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Selective IgG subclass deficiency

MONDO:0001901

A classification of dysgammaglobulinemias characterized by low or undetectable serum levels of one of the four immunoglobulin class G (IgG) subclasses. Selective IgG1 deficiency is rare and primarily decreases the immune response to bacterial protein antigens. Selective IgG2 deficiency is the most common subclass deficiency among children and primarily leads to an inadequate response to bacterial polysaccharide antigens. Selective IgG3 deficiency is the most common subclass deficiency among adults and also primarily lowers the response to bacterial proteins. Selective IgG4 deficiency may be a clinically insignificant developmental variant, as IgG4 is a subclass that is virtually undetectable until the end of the first decade of life. Low levels of any IgG subclass will reduce the immune system's effectiveness and thus the clinical presentation of these diseases is usually recurrent infection, particularly by encapsulated bacteria.

Also known as: selective Immunoglobulin G subclass deficiency, selective IgG deficiency disease, selective IgG immunodeficiency

89 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Hereditary disease (172) Hematologic disorder (160) Immune system disorder (140) Inborn error of immunity (113) Immunodeficiency disease (48) Human disease (14) Leukocyte disorder (5) B cell deficiency (4) Disease of genetic or genomic mechanism (2)
Trials to join now! 46 Not yet recruiting 8 Not yet finished but already full! 9 Completed 25 Terminated 1
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