Schizoaffective disorder
MONDO:0005487A disorder in which the individual suffers from both symptoms that qualify as schizophrenia and symptoms that qualify as a mood disorder (e.g., depression or bipolar disorder) for a substantial portion (but not all) of the active period of the illness; for the remainder of the active period of the illness, the individual suffers from delusions or hallucinations in the absence of prominent mood symptoms.
328 clinical trials for this condition and its sub-types.
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Broader categories
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Heart risk check for schizophrenia drugs
Disease control TerminatedThis study aimed to see how two antipsychotic drugs, aripiprazole and ziprasidone, affect heart risk in people with schizophrenia, schizoaffective disorder, or bipolar disorder. Researchers measured blood fats and heart electrical changes in 48 adults over 12 months. The trial wa…
Phase: PHASE3 • Sponsor: Northwestern University • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Mental health sessions may boost vaccine uptake in latinx communities
Prevention TerminatedThis study tested whether adding vaccine discussions to routine behavioral health visits could reduce hesitancy and increase COVID-19 and flu shots among Latinx adults with mental illness. Clinicians used motivational interviewing and could offer a warm handoff to a nurse for vac…
Phase: NA • Sponsor: Boston College • Aim: Prevention
Last updated Jun 26, 2026 17:00 UTC
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Brain zapping trial for Schizophrenia's 'Negative Symptoms' ends early
Symptom relief TerminatedThis study tested whether a non-invasive brain stimulation technique called TMS could help reduce negative symptoms of schizophrenia, like low motivation and reduced facial expression. The trial enrolled 47 adults with schizophrenia or schizoaffective disorder and compared active…
Phase: NA • Sponsor: Beth Israel Deaconess Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 14:03 UTC
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Brain training for psychosis: a small step toward better school performance
Symptom relief TerminatedThis study looked at whether adding cognitive remediation therapy (a type of brain training) to supported education (help returning to school) improves academic functioning in young adults with psychotic disorders. Only 9 people enrolled before the study was stopped early. The go…
Phase: NA • Sponsor: Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Brain zaps and computer games: a new hope for schizophrenia fog?
Symptom relief TerminatedThis pilot study tested whether combining repetitive transcranial magnetic stimulation (rTMS) with computerized cognitive training could help adults with schizophrenia who have thinking and memory problems. Twelve participants received either active or sham rTMS followed by cogni…
Phase: NA • Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Brain chemical oxytocin tested to ease social struggles in schizophrenia
Symptom relief TerminatedThis study looked at whether oxytocin, a natural brain chemical that helps with social bonding, could improve social functioning in veterans with schizophrenia. Researchers planned to give oxytocin and use brain scans to see who might benefit. The study was stopped early, so resu…
Phase: PHASE2 • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Eye test may predict schizophrenia drug success
Symptom relief TerminatedThis study aimed to see if a simple eye scan could predict which people with early schizophrenia would benefit from a drug called sodium nitroprusside. The drug was given to reduce psychosis symptoms like delusions and hallucinations. Only one person enrolled before the study was…
Phase: PHASE2 • Sponsor: Beth Israel Deaconess Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Robot seal calms dementia patients during care
Symptom relief TerminatedThis study tested whether a robotic seal named PARO could help elderly people with moderate to severe memory problems feel calmer during daily care like bathing. The robot was used for a few minutes before and during care, twice a week for 16 weeks. The goal was to see if it redu…
Phase: NA • Sponsor: Centre Hospitalier Departemental Vendee • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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New tool could help patients stay safe on lithium
Knowledge-focused TerminatedThis study tested a French version of a questionnaire that measures how much patients know about lithium, a drug used for bipolar and schizoaffective disorders. Researchers wanted to see if higher knowledge scores matched safe lithium levels in the blood. The study included 22 ho…
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Mental health study aims to uncover Long-Term heart risks
Knowledge-focused TerminatedThis study followed 167 adults with mental health issues like anxiety, depression, or sleep problems who visited their primary care doctor. Researchers used health conversations and a blood test to track lifestyle changes and heart disease risks over up to 20 years. The goal was …
Phase: NA • Sponsor: Region Skane • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Brain zapping study targets smoking in schizophrenia
Knowledge-focused TerminatedThis study tested whether a non-invasive brain stimulation technique called deep rTMS could change brain activity and reduce smoking in people with schizophrenia. Researchers used brain scans to measure changes in brain connections and smoking behavior. The study was small and en…
Phase: NA • Sponsor: Stony Brook University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Could a gentle brain zap quiet voices in schizophrenia?
Knowledge-focused TerminatedThis small, early study tested a new approach called Auditory Control Enhancement (ACE) for people with schizophrenia who hear voices (auditory hallucinations) that don't respond to medication. ACE combines a mild brain stimulation technique called tDCS with cognitive training. T…
Phase: NA • Sponsor: Brian A Coffman, PhD • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Home help for dementia caregivers: study ends early with few answers
Knowledge-focused TerminatedThis study aimed to see if introducing formal home help (like a paid aide) improves the quality of life for people caring for elderly relatives with memory or thinking problems. Researchers planned to follow 12 caregivers for 90 days, measuring changes in their well-being, stress…
Sponsor: Groupe Hospitalier de la Region de Mulhouse et Sud Alsace • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC
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Online tool for psychosis support tested in clinics – but study stopped early
Knowledge-focused TerminatedThis study looked at whether a digital platform called Horyzons could be used in clinics that help young people with early psychosis. The platform offers therapy content and a safe social network. Researchers wanted to understand what helps or hinders its use in real-world care. …
Phase: NA • Sponsor: University of North Carolina, Chapel Hill • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:15 UTC