Schistosomiasis
MONDO:0015254An infectious disease caused by parasitic trematodes of the genus Schistosoma that colonize human blood vessels and release eggs that can cause granulomatous reactions leading to acute (swimmer's itch or acute schistosomiasis syndrome) or chronic disease. Depending on where the eggs lodge, manifestations of chronic schistosomiasis can include diarrhea, abdominal pain, loss of appetite, anemia (intestines), hepatosplenism, periportal fibrosis with portal hypertension (liver), urogenital inflammation and scarring, hematuria and dysuria (genitourinary system). Other patients may be asymptomatic.
Also known as: Bilharzia, bilharziasis, schistosomiasis, snail fever
18 clinical trials for this condition and its sub-types, 15 tagged with Schistosomiasis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Schistosomiasis
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Urinary schistosomiasis 3 trials
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Cercarial dermatitis 0 trials
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Intestinal schistosomiasis 0 trials
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Neuroschistosomiasis 0 trials
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Can extra doses of an old drug reverse liver scarring?
Disease control Not yet recruitingThis trial tests whether giving praziquantel three times a year, instead of the standard once a year, can improve liver fibrosis (scarring) caused by schistosomiasis in people aged 15-40 in Uganda. Participants with liver fibrosis will be randomly assigned to one of two treatment…
Phase 2/3 • Sponsor: Rhode Island Hospital • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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New study eyes selexipag for neglected form of lung hypertension
Disease control Not yet recruitingThis study looks at how well the oral medication selexipag works over the long term for people with a specific type of lung hypertension caused by schistosomiasis (a parasitic infection). Researchers will compare patients who received selexipag as part of routine care to similar …
Sponsor: Caio Júlio César dos Santos Fernandes • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Simple urine test could revolutionize schistosomiasis detection
Diagnosis Not yet recruitingThis study aims to develop a new urine test for schistosomiasis, a parasitic infection. Researchers will test a nanobody-based strip on 2500 participants, comparing it to the standard microscope method. If accurate, it could offer a quick, non-invasive diagnostic tool.
Sponsor: Pemba Ministry of Health Zanzibar • Aim: Diagnosis
Last updated Jun 27, 2026 12:03 UTC
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Heart-Lung connection may explain survival advantage in Parasite-Linked hypertension
Knowledge-focused Not yet recruitingThis study looks at how well the right side of the heart works with the lungs in people who have high blood pressure in their lung arteries caused by schistosomiasis, a parasitic infection common in parts of Africa and South America. Researchers will use echocardiography to measu…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Egyptian schistosomiasis study launches to map disease hotspots
Knowledge-focused Not yet recruitingThis study will measure how many people in Assiut Governorate, Egypt, have schistosomiasis, a parasitic disease. Researchers will test urine and stool samples from 359 participants and ask about risk factors. The goal is to better understand the current burden of the disease in t…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC