Schistosomiasis

This study tested a new vaccine called SchistoShield® in 120 healthy adults in Burkina Faso and Madagascar. The goal was to see if it is safe and triggers an immune response against schistosomiasis, a parasitic disease spread by snails. Participants received three doses of the va…

This study tested a new vaccine (Sm-TSP-2) to protect against intestinal schistosomiasis, a parasitic worm infection common in parts of Africa. Healthy adults in Uganda received different doses of the vaccine, with or without an immune booster, to check safety and how well it tri…

This study tested two doses (40 vs 80 mg/kg) of praziquantel in 354 children aged 1-4 with schistosomiasis in Uganda. The goal was to find the best dose to cure the infection and improve growth and anemia. Currently, praziquantel is not approved for children under 4, and this tri…

This study tested a vaccine called Bilhvax, given alongside a standard treatment (praziquantel), to see if it could delay the return of schistosomiasis (a parasitic infection) in children aged 6 to 9 in Senegal. The vaccine was given as three shots plus a booster one year later. …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This completed study in Pemba, Tanzania, compared several diagnostic tests for Schistosoma haematobium, a parasitic worm that causes a debilitating disease. Researchers tested 801 schoolchildren using methods like urine filtration, AI microscopy, and molecular tests. The goal was…

This study tested whether giving deworming drugs during regular healthcare visits works better than the usual special campaigns. Over 1,200 people in Western Kenya took part, including community members, health workers, and officials. Researchers measured how practical, affordabl…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This completed study looked at 141 people being treated for tuberculosis (TB) to see if intestinal parasites or poor nutrition made their recovery harder. Researchers checked stool samples for parasites and measured weight gain and treatment success. Some participants received nu…

This study surveyed nearly 1,000 students in Pemba, Zanzibar, to see how much they know about schistosomiasis (a parasitic disease) and how they feel about it. Researchers tested a health education program led by community volunteers to see if it improves students' knowledge, att…