Qualitative platelet defect

This study tested a new lab method to diagnose platelet function disorders in 322 people with bleeding symptoms. The method uses flow cytometry to detect signaling defects in platelets, which are often missed by standard tests. The goal was to standardize the technique across mul…

This trial investigates whether genetic variations in the CES1 gene influence how the body responds to the blood thinners clopidogrel and aspirin. Healthy Amish adults will take clopidogrel for a week, then a single dose of aspirin, with blood tests measuring platelet function be…

This trial investigates whether a common genetic variation in the CES1 gene affects how the body processes two antiplatelet drugs, clopidogrel and ticagrelor. Healthy volunteers of Amish descent will take each drug for eight days in a crossover design, and researchers will measur…

This study looked at 68 adults having planned heart surgery that required a heart-lung machine. Researchers compared two different oxygenators (artificial lungs) to see if one caused more damage to platelets, the blood cells that help stop bleeding. They used a special test calle…

This completed pilot study looked at whether some healthy adults are resistant to aspirin's blood-thinning effects. 48 participants took two different types of 81 mg aspirin for two weeks each, and their platelet function was measured. The goal was to understand how common aspiri…