Progressive non-fluent aphasia
MONDO:0015059Progressive non-fluent aphasia (PNFA) is a form of frontotemporal dementia (FTD), characterized by agrammatism, laborious speech, alexia, and agraphia, frequently accompanied by apraxia of speech (AOS). Language comprehension is relatively preserved.
Also known as: Agramatic variant of PPA, Agramatic variant of primary progressive aphasia, Primary Progressive Nonfluent aphasia, non-fluent variant PPA, non-fluent primary progressive aphasia
60 clinical trials for this condition and its sub-types, 23 tagged with Progressive non-fluent aphasia itself.
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Sub-types of Progressive non-fluent aphasia
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Semantic dementia 32 trials
1 sub-type
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Can a High-Fat drink help Alzheimer's? small study tests safety
Symptom relief CompletedThis study tested a ketogenic drink made from medium chain triglycerides (MCTs) in 43 people with Alzheimer's disease or a type of frontotemporal dementia. The goal was to see if it was safe and tolerable, and to measure ketone levels in the blood. It was a small, early-stage tri…
Sponsor: University of British Columbia • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Can magnetic pulses to the brain boost speech in aphasia?
Symptom relief CompletedThis study tested whether repeated sessions of transcranial magnetic stimulation (TMS) could improve language in people with primary progressive aphasia (PPA), a condition that slowly damages language areas of the brain. Ten participants received both real and sham (fake) TMS ove…
Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:02 UTC
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Brain zaps may help stroke survivors find their words again
Symptom relief CompletedThis pilot study tested whether combining a mild brain stimulation technique (tDCS) with intensive language therapy can help people with non-fluent aphasia after a stroke. Ten participants received both real and sham stimulation during therapy sessions. The goal was to see if the…
Sponsor: University of Minnesota • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Stroke speech therapy: finding the right dose
Symptom relief CompletedThis study tested speech entrainment therapy (SET) in 80 people with non-fluent aphasia after a stroke. Participants practiced speaking along with an audio-visual computer program for 3, 4.5, or 6 weeks, or received no therapy. The goal was to find the best duration for lasting i…
Phase 2 • Sponsor: Medical University of South Carolina • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Gentle zaps to the brain may ease language loss in dementia
Symptom relief CompletedThis study tested whether a gentle, non-invasive brain stimulation technique called tDCS, combined with language therapy, could improve speech in 23 people with primary progressive aphasia (PPA). Participants received either real or fake (sham) stimulation daily for 10 days. Rese…
Sponsor: University of Pennsylvania • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Zapping the brain to save speech: new hope for aphasia?
Symptom relief CompletedThis study tested whether a gentle electrical current applied to the brain (tDCS) can improve language when combined with speech therapy in people with primary progressive aphasia (PPA), a condition that slowly damages language abilities. 76 adults with two types of PPA received …
Phase 2 • Sponsor: University of Pennsylvania • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC
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Brain scans reveal how language therapy rewires Stroke-Damaged brains
Knowledge-focused CompletedThis study investigates how different language treatments affect both language skills and brain function in people with aphasia, a condition that impairs the ability to speak, understand, read, or write after a stroke. Participants will receive therapy targeting naming, spelling,…
Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC