Primary progressive aphasia
MONDO:0019806Primary progressive aphasia (PPA) is a neurodegenerative disorder, characterized by a primary dissolution of language, with relative sparing of other mental faculties for at least the first 2 years of illness. PPA is recognized as the language variant in the frontotemporal dementia (FTD) spectrum of disorders. PPA can be classified into 3 subtypes based on specific speech and language features: semantic dementia (SD), progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (lv-PPA).
Also known as: Mesulam syndrome, PPA, primary progressive aphasia syndrome
76 clinical trials for this condition and its sub-types.
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Could a Head-Zap at home boost your brain?
Symptom relief TerminatedThis study tested whether a gentle, non-invasive brain stimulation technique (tDCS) done at home, along with computer-based brain games, could improve thinking and language skills in people with primary progressive aphasia, mild cognitive impairment, or dementia. Participants use…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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Brainwave training tested for aphasia recovery
Symptom relief TerminatedThis study tested whether EEG neurofeedback—a type of brain training that uses real-time brainwave readings—can help people with aphasia (trouble speaking or understanding language) improve their communication, sleep, and anxiety. Seven adults with aphasia from stroke or primary …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC