Primary progressive aphasia
MONDO:0019806Primary progressive aphasia (PPA) is a neurodegenerative disorder, characterized by a primary dissolution of language, with relative sparing of other mental faculties for at least the first 2 years of illness. PPA is recognized as the language variant in the frontotemporal dementia (FTD) spectrum of disorders. PPA can be classified into 3 subtypes based on specific speech and language features: semantic dementia (SD), progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (lv-PPA).
Also known as: Mesulam syndrome, PPA, primary progressive aphasia syndrome
76 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
-
Experimental antibody aims to repair brain connections in rare dementia
Disease control Not yet recruitingThis study tests a new drug called NS101 in 15 people with semantic variant primary progressive aphasia (svPPA), a rare type of frontotemporal dementia that affects language and memory. The drug is an antibody designed to help repair connections between brain cells. The main goal…
Phase: PHASE2 • Sponsor: Hee-Jin Kim • Aim: Disease control
Last updated Jun 26, 2026 14:05 UTC
-
New brain test aims to unravel language confusion in dementia
Diagnosis Not yet recruitingThis study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…
Sponsor: Hospices Civils de Lyon • Aim: Diagnosis
Last updated Jun 27, 2026 12:30 UTC
-
AI-powered brain zaps aim to slow language loss in dementia
Symptom relief Not yet recruitingThis study tests a personalized brain stimulation device for people with primary progressive aphasia (PPA), a condition that slowly destroys language abilities. Ten participants will receive daily 30-minute sessions over three weeks, where an AI analyzes their brain activity and …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
-
Could a zapping cap boost memory? small study tests brain stimulation for cognitive decline
Symptom relief Not yet recruitingThis pilot study will test whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive low-level electrica…
Phase: NA • Sponsor: Sunnybrook Health Sciences Centre • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
-
Music before bed may ease Alzheimer's agitation, new study hopes
Symptom relief Not yet recruitingThis pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Saint Etienne • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
-
Can ancient chinese music therapy help stroke survivors speak again?
Symptom relief Not yet recruitingThis study tests whether a special type of speech training using five musical tones can help people with aphasia (trouble speaking) after a stroke. Researchers will enroll 120 adults who had a stroke and have non-fluent aphasia. Participants will receive either five-tone therapy …
Phase: NA • Sponsor: Fujian University of Traditional Chinese Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC