Primary progressive aphasia
MONDO:0019806Primary progressive aphasia (PPA) is a neurodegenerative disorder, characterized by a primary dissolution of language, with relative sparing of other mental faculties for at least the first 2 years of illness. PPA is recognized as the language variant in the frontotemporal dementia (FTD) spectrum of disorders. PPA can be classified into 3 subtypes based on specific speech and language features: semantic dementia (SD), progressive non-fluent aphasia (PNFA) and logopenic progressive aphasia (lv-PPA).
Also known as: Mesulam syndrome, PPA, primary progressive aphasia syndrome
70 clinical trials for this condition and its sub-types.
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Broader categories
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Can singing and constraint therapy rebuild speech after stroke?
Disease control Not yet recruitingThis trial investigates whether combining two behavioral therapies can help people with non-fluent aphasia—a condition where stroke damages the brain's language centers, making speech difficult. The approach uses Melodic Intonation Therapy (MIT), which uses singing-like intonatio…
Phase: NA • Sponsor: Universidad de Granada • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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Experimental antibody aims to repair brain connections in rare dementia
Disease control Not yet recruitingThis study tests a new drug called NS101 in 15 people with semantic variant primary progressive aphasia (svPPA), a rare type of frontotemporal dementia that affects language and memory. The drug is an antibody designed to help repair connections between brain cells. The main goal…
Phase: PHASE2 • Sponsor: Hee-Jin Kim • Aim: Disease control
Last updated Jun 26, 2026 14:05 UTC
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New brain test aims to unravel language confusion in dementia
Diagnosis Not yet recruitingThis study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…
Sponsor: Hospices Civils de Lyon • Aim: Diagnosis
Last updated Jun 27, 2026 12:30 UTC
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AI-powered brain zaps aim to slow language loss in dementia
Symptom relief Not yet recruitingThis study tests a personalized brain stimulation device for people with primary progressive aphasia (PPA), a condition that slowly destroys language abilities. Ten participants will receive daily 30-minute sessions over three weeks, where an AI analyzes their brain activity and …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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Can ancient chinese music therapy help stroke survivors speak again?
Symptom relief Not yet recruitingThis study tests whether a special type of speech training using five musical tones can help people with aphasia (trouble speaking) after a stroke. Researchers will enroll 120 adults who had a stroke and have non-fluent aphasia. Participants will receive either five-tone therapy …
Phase: NA • Sponsor: Fujian University of Traditional Chinese Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC