Primary hyperparathyroidism

This study is testing whether a special PET/CT scan using an amino acid tracer can better detect tumors in people with amino acid transport disorders, primary hyperparathyroidism, or glioma. About 500 adults will receive a single injection of the tracer and then get scanned. The …

This study tests whether a new type of PET scan using a radioactive tracer called 18F-FCH can more accurately locate overactive parathyroid glands or tumors before surgery. About 193 adults scheduled for parathyroid removal will receive both the new scans and a standard 4D-CT sca…

Primary hyperparathyroidism happens when one or more parathyroid glands make too much hormone, and surgery to remove the overactive gland is the only cure. When standard imaging cannot show exactly where the gland is, surgeons have a harder time finding it during the operation. T…

This study follows up to 3,000 people who have, are at risk for, or are related to someone with a parathyroid disorder. Researchers will collect medical records, questionnaires, and samples like blood and saliva to learn what causes these conditions and how they change over time.…

Researchers are studying whether blood levels of luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are linked to the presence, severity, and long-term outcomes of endocrine disorders such as osteoporosis, thyroid disease, and adrenal gland problems. The study enroll…

This study looks at whether removing the parathyroid gland can improve physical function and mobility in adults aged 60 and older with primary hyperparathyroidism. Researchers will track changes in walking, strength, and daily activity before and after surgery, and analyze blood …

This study looks at whether patient navigation—a service that helps people schedule and attend appointments—can increase the number of patients with primary hyperparathyroidism who receive surgery. The study will enroll 76 people from historically marginalized groups and track ho…

This study examines stored tumor tissue and blood samples from 310 people with parathyroid tumors. Researchers aim to find molecular and genetic markers that can better distinguish between benign and cancerous tumors. The goal is to reduce misdiagnosis, unnecessary surgery, and s…

This phase 2 study is collecting tumor samples from 839 people with hyperparathyroidism who are having parathyroid surgery. Researchers want to see if the genetic makeup of the tumors (whether they are monoclonal or polyclonal) relates to how many glands are affected and how well…

This study aims to validate a French version of the Parathyroid Assessment of Symptoms (PAS) questionnaire for people with primary hyperparathyroidism. Researchers will ask 548 patients to fill out the PAS.fr and a standard quality-of-life questionnaire before and after surgery. …

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study looks at how different forms of vitamin D work in the body. Researchers will measure free vitamin D (the active form) in healthy adults, pregnant women, and people with hormone or kidney problems. The goal is to see if free vitamin D gives a more accurate picture of vi…

This study follows 403 adults with primary hyperparathyroidism who are having their overactive parathyroid gland removed. Researchers will track heart problems, cholesterol, blood sugar, artery stiffness, and quality of life for up to 5 years after surgery. The goal is to underst…