Primary hyperoxaluria
MONDO:0002474A hereditary disorder characterized by excessive oxalate production, leading to hyperoxaluria.
Also known as: hyperoxaluria, primary, primary hyperoxaluria
16 clinical trials for this condition and its sub-types.
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Broader categories
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Promising drug may protect kidneys in kids with rare oxalate disorder
Disease control CompletedThis study tested a monthly injection called nedosiran in 27 children from birth to 11 years old with primary hyperoxaluria, a rare condition that causes harmful oxalate buildup and kidney damage. The goal was to see if the drug safely lowers oxalate levels in the urine. Early re…
Phase: PHASE2 • Sponsor: Dicerna Pharmaceuticals, Inc., a Novo Nordisk company • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Could a phosphate drug also stop kidney stones?
Disease control CompletedThis study tested whether Tenapanor, a drug approved for kidney disease, can reduce oxalate absorption from food and lower the risk of kidney stones. Eighteen healthy adults without a history of stones took the drug or a placebo, and their urine oxalate levels were compared. The …
Phase: PHASE4 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Kidney stone mystery: why some gene carriers get sick and others stay healthy
Knowledge-focused CompletedThis study looks at people who carry one copy of a mutated AGXT gene, which is linked to a rare kidney stone disease. Some carriers develop kidney stones, while others do not. Researchers will compare their urine oxalate levels and lifestyle factors to find out what triggers symp…
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC