Primary angle-closure glaucoma
MONDO:0001868An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component.
25 clinical trials for this condition and its sub-types, 14 tagged with Primary angle-closure glaucoma itself.
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Sub-types of Primary angle-closure glaucoma
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Chronic closed-angle glaucoma 7 trials
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Acute closed-angle glaucoma 1 trial
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Interval angle-closure glaucoma 0 trials
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New combo surgery may better control glaucoma pressure
Disease control Recruiting nowThis study tests whether adding an extra step (a special blade to open drainage channels) to standard cataract-and-glaucoma surgery can better lower eye pressure in people with chronic angle-closure glaucoma and cataracts. About 68 adults will be randomly assigned to one of two s…
Sponsor: Peking University People's Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Glaucoma surgery showdown: new procedure may offer safer option
Disease control Recruiting nowThis study compares two surgical procedures for people with primary angle-closure glaucoma: Phaco-GSL (cataract surgery combined with a procedure to open the eye's drainage angle) and trabeculectomy (a standard glaucoma surgery that creates a new drainage pathway). Researchers wa…
Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City • Aim: Disease control
Last updated Jun 26, 2026 15:37 UTC
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New eye scans may unlock secrets of glaucoma blindness
Knowledge-focused Recruiting nowThis study will use advanced eye scans (OCT and OCTA) to compare the structure and blood flow of the choroid and retina in people with two main types of glaucoma: primary angle-closure disease and primary open-angle glaucoma. Researchers aim to better understand how these conditi…
Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Scientists probe molecular secrets of glaucoma eye strain
Knowledge-focused Recruiting nowThis study looks at why some people with primary angle-closure glaucoma have loose eye lenses (zonular laxity). Researchers will compare molecules from 150 participants—those with and without this lens looseness, plus healthy controls—to find key differences. The goal is to bette…
Sponsor: Zhongnan Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:10 UTC
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New eye imaging study could unlock secrets of glaucoma
Knowledge-focused Recruiting nowThis study looks at how tiny fibers in the eye, called the vitreous zonule, might play a role in causing primary angle-closure glaucoma, a serious eye condition. Researchers will use advanced 3D ultrasound to take detailed pictures of these fibers in 440 adults, including those w…
Sponsor: Peking University People's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC