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Preretinal fibrosis
MONDO:0002174A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)
Also known as: macular puckering of retina
37 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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New app could spot eye disease from your couch
Diagnosis ENROLLING_BY_INVITATIONThis study is testing a smartphone app called NEDS EyeCTester to see if it can help detect active eye disease early in people with conditions like optic nerve or macular disease. About 100 participants will use the app at home, and researchers will compare the results to standard…
Sponsor: Neuro-Eye Diagnostic Systems, LLC • Aim: Diagnosis
Last updated Jun 27, 2026 12:06 UTC
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Stem cell eye therapy: 5-Year safety watch begins
Knowledge-focused ENROLLING_BY_INVITATIONThis study follows people who received a stem cell treatment for macular degeneration to see if any late side effects appear more than 5 years later. Participants fill out a yearly questionnaire about eye problems, infections, immune disorders, cancer, or other health changes. Th…
Phase: PHASE1, PHASE2 • Sponsor: Astellas Institute for Regenerative Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Eye fluid analysis may unlock secrets of rare eye condition
Knowledge-focused OngoingThis pilot study examines proteins in the vitreous (the gel-like fluid inside the eye) of patients with pseudoexfoliation syndrome (PEX), a condition that can lead to glaucoma. Researchers will compare protein levels between eyes with and without PEX in 24 adults undergoing eye s…
Phase: NA • Sponsor: Prim. Prof. Dr. Oliver Findl, MBA • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Eye surgery showdown: UNITY VCS vs CONSTELLATION trial pulled
Knowledge-focused TerminatedThis study aimed to compare two surgical systems, UNITY VCS and CONSTELLATION, for treating various eye conditions like macular holes and retinal detachment. It was designed for adults needing vitreoretinal surgery. However, the trial was withdrawn before enrolling any participan…
Phase: NA • Sponsor: Alcon Research • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Free eye tests aim to catch vision loss early in harlem and washington heights
Knowledge-focused OngoingThis study offers free vision screenings to underserved adults over 40 living in affordable housing in Harlem and Washington Heights. The goal is to find eye problems like glaucoma, cataracts, and diabetic retinopathy early and connect people with follow-up care. About 749 partic…
Phase: NA • Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Laser after eye surgery may boost recovery, small study hints
Knowledge-focused ENROLLING_BY_INVITATIONThis study follows 100 people having surgery to remove a scar-like membrane on the retina (epiretinal membrane). Half will also receive a gentle laser treatment one month after surgery. Researchers will measure vision and eye structure changes over four months to see if the laser…
Phase: NA • Sponsor: Pomeranian Medical University Szczecin • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:39 UTC