Preretinal fibrosis
MONDO:0002174A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)
Also known as: macular puckering of retina
37 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Soothing sounds: slow music eases anxiety during eye procedures
Symptom relief CompletedThis study tested whether playing slow tempo music before and during an eye injection (intravitreal injection) can reduce anxiety and pain. 144 adults took part, with half listening to music and the other half receiving standard care. Researchers measured anxiety using saliva tes…
Phase: NA • Sponsor: Ng Yu Siang • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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New eye scanner aims to sharpen view of retinal disease
Knowledge-focused CompletedThis trial tests a new device called P200TxE that takes detailed images of the back of the eye. Researchers want to see how well it captures images in people with retinal diseases like glaucoma or macular degeneration. The study involves adults aged 22 and older who have been dia…
Phase: NA • Sponsor: Optos, PLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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AI boosts eye Doctors' accuracy in reading retinal scans?
Knowledge-focused CompletedThis study tested whether artificial intelligence (AI) can help doctors detect retinal diseases from ultra-widefield eye images. 462 images were read by four eye doctors with different experience levels, both with and without AI assistance. The goal was to see if AI improves accu…
Sponsor: Xiamen Ophthalmology Center Affiliated to Xiamen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Blood thinners may be safe during retina surgery, study suggests
Knowledge-focused CompletedThis completed French study followed 748 adults undergoing retina/vitreous surgery to see if taking blood thinners (anticoagulants or antiplatelets) raises the risk of bleeding complications. Researchers compared patients who continued or stopped their medication with those not o…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Scientists probe eye fluids to unlock secrets of retinal detachment
Knowledge-focused CompletedThis completed study looked at fluid samples from the eyes of 137 people undergoing surgery for retinal detachment or other eye conditions. Researchers measured fats and proteins in these fluids to understand inflammation and cell death that can harm vision after surgery. The goa…
Phase: NA • Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC