Preretinal fibrosis
MONDO:0002174A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291)
Also known as: macular puckering of retina
32 clinical trials for this condition and its sub-types.
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New eye scanner could sharpen diagnosis of glaucoma and retina diseases
Diagnosis CompletedThis study is testing a new eye imaging device called the VG200D, which uses advanced technology to take detailed pictures of the eye. Researchers want to see if it works as well as a standard device for measuring parts of the eye in people with glaucoma, retina problems, corneal…
Sponsor: Intalight, Inc • Aim: Diagnosis
Last updated Jul 31, 2026 00:00 UTC
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AI eye exam: could a computer beat your doctor at spotting diabetic blindness?
Diagnosis CompletedThis study tested an artificial intelligence (AI) algorithm to detect diabetic retinopathy and glaucoma from eye photos. Researchers compared the AI's accuracy to that of family doctors and retina specialists. The goal was to see if AI could be a reliable screening tool in primar…
Sponsor: Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina • Aim: Diagnosis
Last updated Jul 11, 2026 00:00 UTC
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Eye drops before surgery may boost vision recovery
Symptom relief CompletedThis trial tests whether adding nepafenac eye drops before and after surgery for epiretinal membrane (a wrinkle on the retina) can help the eye heal faster. Sixty adults with this condition will either receive the drops plus standard care or standard care alone. Researchers will …
Phase: PHASE4 • Sponsor: Ankara Yildirim Beyazıt University • Aim: Symptom relief
Last updated Aug 01, 2026 00:00 UTC
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Soothing sounds: slow music eases anxiety during eye procedures
Symptom relief CompletedThis study tested whether playing slow tempo music before and during an eye injection (intravitreal injection) can reduce anxiety and pain. 144 adults took part, with half listening to music and the other half receiving standard care. Researchers measured anxiety using saliva tes…
Phase: NA • Sponsor: Ng Yu Siang • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Built-In eye scanner could give surgeons a live 3D view during operations
Knowledge-focused CompletedThis study tests a microscope that has an OCT scanner built directly into it, allowing surgeons to take detailed cross-sectional images of the eye during surgery. The goal is to see if this setup is practical and whether the extra visual information helps guide surgical decisions…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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New eye scanner aims to sharpen view of retinal disease
Knowledge-focused CompletedThis trial tests a new device called P200TxE that takes detailed images of the back of the eye. Researchers want to see how well it captures images in people with retinal diseases like glaucoma or macular degeneration. The study involves adults aged 22 and older who have been dia…
Phase: NA • Sponsor: Optos, PLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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AI boosts eye Doctors' accuracy in reading retinal scans?
Knowledge-focused CompletedThis study tested whether artificial intelligence (AI) can help doctors detect retinal diseases from ultra-widefield eye images. 462 images were read by four eye doctors with different experience levels, both with and without AI assistance. The goal was to see if AI improves accu…
Sponsor: Xiamen Ophthalmology Center Affiliated to Xiamen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Blood thinners may be safe during retina surgery, study suggests
Knowledge-focused CompletedThis completed French study followed 748 adults undergoing retina/vitreous surgery to see if taking blood thinners (anticoagulants or antiplatelets) raises the risk of bleeding complications. Researchers compared patients who continued or stopped their medication with those not o…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Scientists probe eye fluids to unlock secrets of retinal detachment
Knowledge-focused CompletedThis completed study looked at fluid samples from the eyes of 137 people undergoing surgery for retinal detachment or other eye conditions. Researchers measured fats and proteins in these fluids to understand inflammation and cell death that can harm vision after surgery. The goa…
Phase: NA • Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC